heme onc

Question 1

Heinz bodies

Answer 1

G6PD deficiency, X linked, cresyl violet small peripheral purple inclusions in erthryocytes, oxidize and denatured hemoglobin

Question 2

parvovirus

Answer 2

small single stranded naked DNA viruses, B19 pathogenic, slapped cheek, aplastic crisis in sickle, arthropathy, red blood aplasia, transient aplastic cell crisis, severe anemia

Question 3

ITP

Answer 3

nosebleeds, menorrhagia, petechiae, increased bleeding time, women, autoab against g IIb/IIIa

Question 4

bartonella henselae

Answer 4

gram negative rod, cat-scratch fever, regional lymphadenopathy, necrotizing supprative granulomatous response, microabscesses, bacillary angiomatosis
treatment: azithromycin/doxycycline

Question 5

CML

Answer 5

9:22, BCR-ABL1, constitutively active TK, increase in mature neuts, immature neus, metamyelocytes, basophilia, imatinib

Question 6

eosinophil

Answer 6

graunulocyte of WBC, crystalline core, MBP, destruction of parasites

Question 7

epo secreting tumors

Answer 7

RCC, HCC, hemangioblastoma, pheochromocytoma, –> polycythemia

Question 8

bence jones proteins

Answer 8

excess free kappa or lambda chains

Question 9

TdT

Answer 9

early stage T and B cell marker

Question 10

follicular lymphoma

Answer 10

neoplastic cells resemble germinal center B cells; most common indolent form of NHL in US, nontender lymphadenopathy, t14;18, BCL2-blocks apoptosis, prolonged cell survival, CD10, CD19, CD20 and surface Ig, CD5-, chemo, ritux, pos for BCL2

Question 11

Burkitt

Answer 11

MYC, 8:14, 8:22, endemic, sporadic, immunodef

Question 12

anemia of chronic disease labs

Answer 12

microcytic anemia, low TIBC, high ferritin, low serum iron (to hid from the disease)

Question 13

iron def anemia labs

Answer 13

low mcv, low serum iron, high TIBC

Question 14

thalassemia minor labs

Answer 14

low mcv with normal serum iron and normal iron binding capacity

Question 15

sideroblastic anemia labs

Answer 15

low MCV, high serum iron, normal to decreased TIBC