Heme/Lymph (10/12/2013)

Question 1

Mechanism of heparin? Does it lyse clots?

Answer 1

Increase ANTITHROMBIN III (AT III) activity to INACTIVATE THROMBIN; however, it does not lyse clots

Question 2

what is aPTT? it measures?

Answer 2

activated partial thromboplastin time; Measures INTRINSIC SYSTEM & common pathway including factors XII, XI, IX, VIII, X, V, II (prothrombin), I (fibrinogen)

Question 3

Parvovirus B19 leads to what: (1) in childhood? (2) in chronic hemolytic diseases/sickle cell anemia? (3) in utero infections?

Answer 3

(1) Childhood febrile rash (erythema infectiosum) (2) Aplastic crisis (3) Hydrops fetalis, still birth

Question 4

Abnormal lymphocytes with tartrate-resistant acid phosphatase activity

Answer 4

Hairy cell leukemia

Question 5

Describe platelets and RBCs in: (1) ITP (2) Microangiopathic hemolytic anemia (3) TTP (4) Thrombasthenia & vWD

Answer 5

(1) low platelets, normal RBCs (2) normal platelets, fragmented RBCs (3) low platelets, fragmented RBCs (4) normal # platelets with decreased platelet function, normal RBCs

Question 6

Blood typing agglutination test limitations

Answer 6

Not distinguish between AO & AA (for type A blood) or between BO & BB (for type B blood)

Question 7

AML & DIC

Answer 7

M3 subtype of AML, because large # of Auer rods release granules after chemotherapy; DIC occurs less commonly in M4 & M5 AML subtypes

Question 8

DIC & pregnancy

Answer 8

DIC can develop secondary to abruptio placentae; Labs show high PTT, PT, & TBT (total body temp?)