Heme Lab M3

Question 1

Rule of 3’s

Answer 1

325mg TID, 3 wks for incr HCT, 3 mos for incr Fe stores

Question 2

After treating with iron, if ferritin still low at 3 mos

Answer 2

Check compliance, think re-bleed vs thalassemia

Question 3

Vegan with anemia

Answer 3

B12

Question 4

Treatment of B12 def

Answer 4

B12 shot qDay x 5 days –> 1 shot/month after that

Question 5

Features of TTP/HUS

Answer 5

Fever, Anemia, T-cytopenia, Renal Failure, Neuro

Question 6

How to treat TTP/HUS if plasmapharesis not available

Answer 6

FFP for first 24 hours until plasmapharesis

Question 7

Pointed bars of Hb crystals + target cells

Answer 7

Homozygous HbC

Question 8

Targets + Amorphous precipitates of Hb

Answer 8

SC Disease

Question 9

Toxic Granulations + Dohle Bodies

Answer 9

Evidence of upregulated protein synthesis, will stain blue on wright stain

Question 10

Leukemoid reaction vs CML

Answer 10

Incr Alk Phos in Leukemoid

Question 11

Myeloblast

Answer 11

High nuclear/cytoplasmic ratio + Fine granular chromatin + Prominent nucleoli

Question 12

Fatigue + Bruising + Infection

Answer 12

Acute Leukemia

Question 13

Which leukemia => DIC + Death from intracranial hemorrhage

Answer 13

AML M3

Question 14

AML M4

Answer 14

20% myeloblasts + 20% monocytes

Question 15

Features of CLL

Answer 15

Smudge, LAD, Anemia, CNS infiltration, Mental Status change

Question 16

CD55 + TRAP stain

Answer 16

Hairy Cell Leukemia

Question 17

Tx of Hairy Cell

Answer 17

Cladribine

Question 18

L1 ALL

Answer 18

Childhood

Question 19

L3 ALL

Answer 19

Vacuoles in cytoplasm + Blue nucleus = Burkitts

Question 20

Burkitts cyto

Answer 20

8:14

Question 21

Mantle cyto

Answer 21

11:14

Question 22

Follicular cyto

Answer 22

14:18