Heme Cancer Drugs

Question 1

ALL

Answer 1

Prednisone, Vincristine, and Asparaginase

pluse intrathecal methotrexate

Question 2

AML

Answer 2

Cytarabine and idarubicin or daunorubicin

Question 3

Burkitt Lymphoma

Answer 3

Cyclophosphamide and methotrexate
Vincristine and Doxorubicin
possibly Cytarabine

Question 4

CML

Answer 4

Imatinib
Newer TKIs
Interferon

Question 5

CLL

Answer 5

Fludarabine + cyclophosphamide and/or rituximab

Question 6

Hairy Cell Leukemia

Answer 6

Cladribine, interferon, pentostatin

Question 7

Hodgkin’s Lymphoma

Answer 7

ABVD: doxorubicin, bleomycin, vincristine, dacarbasine, and prednisone

Question 8

NHL

Answer 8

R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone)

Question 9

APL

Answer 9

ATRA, arsenic trioxide, idarubicin

Question 10

MOA of ATRA

Answer 10

Degrades PML-RARA fusion protein

Question 11

MOA of asparaginase

Answer 11

Denies asparagine availability for protein synthesis

Question 12

MOA of bleomycin

Answer 12

Drug-iron complex oxidizes nucleotide deoxyribose

Question 13

MOA of cyclophosphamide

Answer 13

bio-activated alkylating agent

Question 14

MOA of cytarabine

Answer 14

Bio-activated AraCTP inhibits DNA polymerase

Question 15

MOA of dacarbazine

Answer 15

Bio-activated DNA methylator

Question 16

MOA of Daunorubicin, Doxorubicin, Idarubicin

Answer 16

DNA intercalators, topo II inhibitors, free radical generators

Question 17

MOA of Fludarabine

Answer 17

Bio-activated in the cell, produces DNA strand termination

Question 18

MOA of Interferon

Answer 18

direct antiproliferative effect + immunomodulator

Question 19

MOA of Imatinib

Answer 19

BCR/Abl tyrosine kinase inhibitor

Question 20

MOA of Methotrexate

Answer 20

DHFR inhibitor

Question 21

MOA of Pentostatin

Answer 21

Adenosine deaminase inhibitor causing cell apoptosis

Question 22

MOA of Prednisone

Answer 22

inhibition of lymphocyte proliferation

Question 23

MOA of Rituximab

Answer 23

Binds CD20 receptor on B cells causing cell-death

Question 24

MOA of Vincristine

Answer 24

Inhibits mitotic spindle formaiton

Question 25

Toxicity of ATRA

Answer 25

Acute PML differentaiton syndrome

Leukocytosis

Question 26

Toxicity of Asparaginase

Answer 26

bleeding, glucose intolerance

Question 27

Toxicity of bleomycin

Answer 27

pneumonitis, pulmonary fibrosis, alopecia

Question 28

Toxicity of cyclophosphamide

Answer 28

BM Suppression, hemorrhagic cystitis, alopecia

Question 29

Toxicity of cytarabine

Answer 29

BM Suppression (opportunistic infeciton)

Question 30

Toxicity of dacarabazine

Answer 30

BM Suppression, hepatotoxicity, secondary malignancy

Question 31

Toxicity of anthracyclines

Answer 31

BM Suppression, cumulative cardiotoxicity

Question 32

Toxicity of fludarabine

Answer 32

BM Suppression, coma, seizures

Question 33

Toxicity of interferon.

Answer 33

fatigue, fever, neutropenia, flu-like symptoms, myalgia

Question 34

Toxicity of imatinib

Answer 34

BM Suppression, birth defects

Question 35

Toxicity of methotrexate

Answer 35

BM Suppression, oral/GI ulcers, hepatotoxicity, pulmonary dysfunciton

Question 36

Toxicity of pentostatin

Answer 36

hepatotoxicity, pulmonary edema, renal failure, seizure

Question 37

Toxicity of prednisone

Answer 37

mutliple metabolic and musculoskeletal effects

Question 38

Toxicity of rituximab

Answer 38

BM Suppression, fever, chills, hypersensitivity reaction

Question 39

Toxicity of vincristine

Answer 39

peripheral neuropathy, patalytic ileus