Heme Flashcards
Common myeloid stem cells give ríase to what
RBC WBC PLate let’s
Common lymphom cells give rise to what
B T cells
Rbc life span
120
Fetal rbc start where
Fetal yo k sack then liver
BT time
2-7 mins
PTT USE and what is the time
Intisristic pathway. Used for heparin normal is 25-40 sec
PT use and time
Warfarin rang 11-15 sec
Vitamin K dependant protein.
2 7 9 10 protein c and s
Protein c
Decreases production of thrombin
Factor the prevent clot formation
Ok
ProstaglandinI2
Heparin
Protein c and s
Sights of a Anemia
Fatigue pallor malaise shortness of breath.
Most accurate way to monitors anemia
Hb
MCV
Measures average rbc volume and is obtained by Hcc/rbc court
MCHC
Hb/HCT and a elevation will mean hereditary spherocytosis
Corrected reticular count
Determine bone marrow responds =hct/45) c reticular count. Usally in anemia it’s greater then 3% lose would mean bone marrow failed
What has hbA?
2 a and 2b
97 percent normal adult have it
HB2A
Hb type
2 a 2delta normally 2 percent in adult
Hbf
2 a 2 gamma normally 1 percent in adult increases affinity for oxygen decrease affinity for 23 bisphosphoglyceric acid
HBS
Found in sickle cell
BHB
Thalassemia major
By Bart
For globulins chains incapable with life hydropower fetal is
MCV
Measures rbc volume rang 80-100
Fl.
Types of microcitic anemia
MCV<80
Iron deficiency anemia
Anemia of crónica disease
Sensider blastocyst anemia acquired)
Iron Deficiency anemia
Decrease ferritin
Hemosedin is a insoluble form of ferritin
Tranferrin iron binding proteins
Transferring
Binds up to 300 and is know as TIBC it is related inversely to ferritin so when ferritin is down tibc is up and so on.
Síntomas of IDA
Polar - tired short ness of breath
Glossies- straw berry tongue
Koilonychia- concave nails
Pica- eating dirt
