Heme

Question 1

t(v;11q23.3)

Answer 1

KMT2A rearranged
rearrangement is most common in infants, who often present with very high white blood cell count and higher rate of CNS involvement

Question 2

t(12;21)

Answer 2

ETV6-RUNX1

is common in children, accounting for ~ 25% of B-ALL but rare in infants or adults

CD13+

Question 3

t(9;22) in which ALL?

Answer 3

BCR-ABL1 [a.k.a. Philadelphia-positive ALL or Ph(+) B - ALL]

CD13+ and CD33+

Question 4

t(5;14)

Answer 4

IL3-IGH

Question 5

t(1;19)

Answer 5

E2A-PBX1

Question 6

iAMP21

Answer 6

B-ALL with intrachromosomal amplification of chromosome 21

older children with median age of 9 years and low WBC counts

Question 7

translocations involving tyrosine kinase or cytokine receptors

Answer 7

B-ALL with translocations involving tyrosine kinase or cytokine receptors (BCR-ABL1-like ALL)

Question 8

B ALL - Favorable Cytogenetic abnormalities

Answer 8

Hyperdiploidy (> 50 chromosomes, especially with trisomy 4, 10, 17)

t(12;21) or ETV6-RUNX6 fusion

Question 9

B ALL - Unfavorable Cytogenetic abnormalities

Answer 9

Hypodiploidy (< 45 chromosomes)
t(9;22) or BCR-ABL-1 fusion
KMT2A rearrangement; t(4;11) or KMT2A/AF4 fusion
B-ALL with iAMP21
Complex abnormalities
BCR-ABL1-like B-ALL

Question 10

B ALL - Intermediate Cytogenetic abnormalities

Answer 10

t(5;14) or IL3-IGH fusion
t(1;19) or TCF3-PBX1 (a.k.a. E2A-PBX1) fusion
Normal karyotype
Any other abnormalities not in favorable or unfavorable categories

Question 11

t(2;5)

Answer 11

NPM1-ALK