Heme

Question 1

Path RBC forms:

spur cell

Answer 1

liver disease, abetalipoproteinemia

Question 2

What is abetalipoproteinemia:

Answer 2

AR disorder that interferes with fat absorption

Question 3

Path RBC forms:

Basophilic stippling

Answer 3

lead poisoning

Question 4

Path RBC forms:

degmacyte “bite cell”

Answer 4

G6PD

Question 5

Path RBC forms:

elliptocyte

Answer 5

Hereditary elliptocytosis

Question 6

Path RBC forms:

macro-ovalocyte

Answer 6

megalo anemia

bone marrow failure

Question 7

Path RBC forms:

ringed siderblast

Answer 7

sideroblastic anemia

excess iron in mitochondria

Question 8

Path RBC forms:

sickle cell

Answer 8

sickle cell anemia

Question 9

G6PD

• inheritance
• precipitated by…
• lab/smear results

Answer 9

• XR
• G6PD–>decreased glutathione –> increased RBC susc. to oxidative stress –> hemolytic anemia following stress
• precipitants: oxidant stress, fava beans
• Lab/smear results: bite cells

Question 10

chromosome translocation 8;14

Answer 10

burkitt lymphoma

C-myc activation

Question 11

chrom translocation 9;22

Answer 11

philadelphia chromosome - CML

BCR-ABL hybrid

Question 12

chrom translocation 11;14

Answer 12

mantle cell lymphoma

Cyclin D1 activation

Question 13

chrom translocation 14;18

Answer 13

follicular lymphoma

BCL-2 activation

Question 14

chrom translocation 15;17

Answer 14

M3 type of AML