Heme 2/Ex 2 Bone marrows + special stains

Question 1

Inactive marrow is aka

Answer 1

fat marrow which occurs from 4-18 years of age

Question 2

Retro-regression is process of:

Answer 2

replacing active marrow by fat tissue during development; results in restrictive active marrow sites

Question 3

Three reasons for bone marrow extraction

Answer 3

1. In patients with solid malignant tumors
   Example → lymphomas, carcinomas and sarcomas, with possible “mets” to bone marrow
2. As part of initial workup of unexplained ↑ or ↓ in RBCs, WBCs, and/or platelets
3. As part of differential diagnosis workup for infections that manifest clinically as “fevers of unknown origin”

Question 4

Three findings used to verify bone marrow has been obtained (rather than p.b.)

Answer 4

Fat droplets
Bone spicules
Very immature hematopoietic cells

Question 5

Four preferred locations for bone marrow tap (in order of preference):

Answer 5

1. Posterior iliac crest (adults and children)
2. Sternum (adults)
3. Vertebrae (in adults)
4. Tibia (children <1 year old)

Question 6

Less than 24 hours before a bone marrow procedure, what is required?

Answer 6

CBC and manual differential