Hematopoietic Disorders

Question 1

Cancers of mature B, T and NK cells

Answer 1

non Hodgkins lymphoma

Question 2

7 the most common cause of cancer deaths

Answer 2

Non Hodgkins lymphoma

Question 3

Non Hodgkins lymphoma rises steadily after which age ?

Answer 3

40

Question 4

Non Hodgkins lymphoma most common in children is?

Answer 4

DLBCL and BL

Question 5

Non Hodgkins lymphoma in adults is?

Answer 5

DLBCL and FL

Question 6

EBV causes which lymphoid malignancies?

Answer 6

Burkitts, post-organ transplant lymphoma, primary CNS diffuse large B cell lymphoma, extra nodal NKT lymphoma

Question 7

What are B symptoms in Non Hodgkins lymphoma

Answer 7

Fever, night sweats,
unexplained weight loss

Question 8

what are the independent prognostic factors in NHL?

Answer 8

B2 microglobulin level and serum lactate dehydrogenase

Question 9

for accurate staging to assess lymphadenopathy for indolent lymphomas these imaging modalities are used

Answer 9

Chest, abdominal and pelvic CT scans

Question 10

this group of B-cell NHL require immediate or urgent tx w chemo and is potentially curable

Answer 10

aggressive

Question 11

which is the most common type of aggressive B-cell NHL

Answer 11

NHL and diffuse large B-cell lymphoma

Question 12

which is the most rapidly proliferative aggressive B-cell NHL

Answer 12

NHL and Burkitt’s lymphoma

Question 13

This type of B-cell NHL is observed and treated only when they symptoms or signs of organ fun impairment, very responsive to therapy

Answer 13

indolent

Question 14

Tingible body macrophages - classic starry sky appearance

Answer 14

NHL- Burkitt’s lymphoma

Question 15

Burkitt’s lymphoma is + for which B antigens

Answer 15

CD-10,19,20,BCL6 and surface immunoglobulin

Question 16

Tx for Burkitt’s lymphoma

Answer 16

cyclophosphamide, EPOCH-R (rituximab, infusional etoposide/ vincristine/doxorubicin, cyclophosphamide, Prednisone)

Question 17

most common histologic type subtype of NHL-

Answer 17

Diffuse large B-cell lymphoma

Question 18

Endemic form of Burkitt lymphoma is tumor of which organ?

Answer 18

Jaw or facial bone that spreads to ovary, testis, kidney and breast esp to bone marrow and meninges

Question 19

Non endemic form of Burkitt’s lymphoma presents w

Answer 19

ascites, renal,testis and /or ovarian involvement

Question 20

what’s the standard first line for Large-B cell lymphoma

Answer 20

R-CHOP