Hematopoiesis

Question 1

Normal HCTfor M and W

Answer 1

M: 45%
W: 40%

Question 2

Normal HgB for M and W

Answer 2

M: : 13.5-17.5 g/dL
F: 12.0-16.0 g/dL

Question 3

What phase are most stem cells stuck in and why

Answer 3

G0

Prevent injury from insult (radiation or chemical)

Question 4

Locations for hematopeosis

Inception
1-2 months fetal life
7-9 months
Child 
Adult

Answer 4

Inception: Yolk sac
1-2 months fetal life: fetal liver
7-9 months: bone marrow
Child: All bones
Adult: Long bones & hips

Question 5

What glyco-protein can be used to seperate HSC

Answer 5

CD34

Question 6

Extra medullary Hematopoiesis and Frontal bossing

• define
• Common in which disease

Answer 6

Frontal bossing in beta-thalassemia
• Infective erythropoiesis
• Expand bone marrow in the bone
• Forehead and cheeks expand because of hyperactive bone marrow

Splenomegaly
• Leukemia
• In response to Fibrosis in bone marrow

Question 7

Explain how hypoxia triggers increased RBC production

Answer 7

• Decreased oxygen ( ie. CO poisoning)
• Kidney produces more erythropoietin
• Increases erythropoiesis

Question 8

What is the difference between anemia with increased or decrease Epo levels?

Answer 8

• With increased reticulocytes in periphery – implies problem not with RBC production
• With low reticulocytes in periphery – check Epo levels (should be very high)

Question 9

IL-1 stimulates

Answer 9

B & T cells

Question 10

IL-3 stimulates

Answer 10

Lymphoid cells

Question 11

IL-2 stimulates

Answer 11

T cells & NK cells

Question 12

GM-CSF stimulates

Answer 12

Monocytes (macrophages)
Granulocytes
Megakaryocytes

Question 13

G-CSF stimulates

Answer 13

PMNs (neutrophils)

Question 14

Epo stimulates

Answer 14

RBC