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Immunology Hematopoiesis > Hematopoiesis > Flashcards

Hematopoiesis Flashcards

1
Q

Neutrophils

A 
Origin and maturation: Bone marrow
Antigen receptors: No
Function: Phagocytosis and killing of microorganisms
Where: marrow and blood circulation
Sites of function: infection sites
Short life span (a few days)
CD15
Induced by IL-3, GM-CSF, and G-CSF
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2
Q

Monocytes

A 
Origin : bone marrow
Antigen receptors: No
Function: to become macrophages and dendritic cells
Present in blood circulation
CD14
Induced: IL-3, GM-CSF, and M-CSF
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3
Q

Eosinophils

A

Origin : bone marrow
Antigen receptors: No
Function: killing of antibody-coated parasites through release of killing mix (cytotoxic granules)
IgE&IgG receptors
Effector machinery: cytotoxic granules, lipid mediators, cytokines and chemokines
Induced: IL-5 (T cells/Mast cells/Eosinophils)

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4
Q

Mast cell

A

Origin : bone marrow; found in skin, lungs, and digestive tract
Antigen receptors: No
Function: to kill parasites (&mediates allergic responses)
Sensor: IgE receptor
Effector machinery: cytotoxic granules, lipid mediators, cytokines and chemokines
Found in connective tissues
Induced: Stem cell factor (SCF)

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5
Q

Basophils

A

Origin : bone marrow
Antigen receptors: No
Circulating granulocytes
Function: important effector cells in allergic disorders and immune responses to parasites
Sensor: IgE receptor
Effector machinery :cytotoxic granules, lipid mediators, cytokines and chemokines

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6
Q

NK cells

A

Origin : Bone marrow and thymus
Antigen receptors: No
Function: Kill tumor and virus-infected cells
Effector machinery (=weapons): perforins and granzymes
Activating (Fc receptors) and inhibitory (some MHC receptors) receptors
Induced: CD16, CD56

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7
Q

T lymphocytes

A

Origin: Bone marrow
Maturation: Thymus
Differentiation to effector cells in secondary lymphoid tissues (lymph nodes, spleen, Peyer’s patch, and tonsils)
Antigen receptors: Yes
Function: regulate humoral and cell-mediated immune responses
Mechanisms: cytokines, cell surface molecules, cytotoxic granules.
Major surface markers: CD3, CD4, CD8

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8
Q

B lymphocytes

A

Origin and maturation: Bone marrow
Differentiation to plasma B cells in secondary lymphoid tissues (lymph nodes, spleen, Peyer’s patch, and tonsils)
CD19+CD20+
Antigen receptors: B cell receptor (cell surface immunoglobulins)
Function: Production of antibodies (IgM, IgE, IgA, and IgG)
Regulated by T cells and DCs

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9
Q

HLA DR3/DR2

A

Systemic Lupus Erythematosus

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10
Q

HLA DR4

A

Rheumatoid Arthritis

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11
Q

HLA B7 and DR2

A

Multiple Sclerosis

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12
Q

HLA B8, DR3/DR4

A

Type I Diabetes

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13
Q

HLA B27

A

Ankylosing Spondylitis

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Immunology Hematopoiesis (2 decks)

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