HEMATOPOIESIS Flashcards

1
Q

2 types of approaching hematopoiesis

A
  • ontogeny
  • phylogeny
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2
Q

an approach in hematopoiesis wherein it focuses on embryonic/development POV

A

ontogeny

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3
Q

an approach in hematopoiesis wherein it focuses on evolution POV

A

phylogeny

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4
Q

formation and development of all blood cells

A

hematopoiesis

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5
Q

encompasses the overall interactions of cell renewal, cellular proliferation, differentiation, morphogenesis, functional maturation, and death

A

hematopoiesis

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6
Q

where erythroid precursor is proliferating, differentiating, and nucleating - nucleus is excluded

A

Erythropoietic island

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7
Q

in what organ is the erythropoietic island found?

A

Bone marrow

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8
Q

percentage of nucleated cells in the bone marrow

A

5-38%

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9
Q

percentage of WBCs responsible for granulopoiesis

A

23-85%

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10
Q

percentage of WBCs responsible for lymphopoiesis

A

1-5%

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11
Q

platelet formation

A

Thrombopoiesis

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12
Q

precursor cell

A

Hemocytoblast

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13
Q

3 types of stem cells

A
  • totipotential
  • pluripotential
  • multipotential
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14
Q

stem cell that is more versatile and present few hours after fertilization

A

totipotential stem cell

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15
Q

this stem cell can differentiate into any type of tissue including blood cells

A

totipotential stem cell

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16
Q

this stem cell is the source of developing cell for fetus

A

totipotential stem cell

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17
Q

this stem cell occurs several days after fertilization

A

pluripotential stem cell

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18
Q

it can develop into any tissue except fetus

A

pluripotential stem cell

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19
Q

this stem cell is found in adults but limited to specific type of cells / is localized in 1 organ

A

multipotential stem cell

20
Q

stem cell is present in the BM and can synthesize cartilage and adipose

A

multipotential stem cell

21
Q

this stem cell’s function is to proliferate different types of blood cells

A

multipotential stem cell

22
Q

phases of hematopoiesis under Intrauterine Phase

A
  • mesoblastic/megaloblastic phase
  • Hepatic phase
  • myeloid/medullary phase
23
Q

connective tissue cells that forms new blood vessels

A

angioblasts

24
Q

precursor cell

A

hemocytoblast

25
Q

3 common embryonic hemoglobin and their corresponding chains

A

*Gower 1 - 2Z and 2E
*Gower 2 - 2A and 2E
* Portland - 2Z and 2Y

26
Q

this phase of hematopoiesis occurs intravascularly

A

Mesoblastic

27
Q

begins during the embryonic development in the blood islands of the yolk sac at around the 19th day of gestation

A

mesoblastic

28
Q

chief site of the megaloblastic phase

A

Yolk sac

29
Q

Primitive RBC is also known as

A

Megaloblast of Ehrlich

30
Q

the primitive RBC first develop within the blood island followed by &

A

Leukopoiesis and megakeryopoiesis

31
Q

what are synthesized during the megaloblastic phase

A

Embryonal Hemoglobins

32
Q

when does the megaloblastic phase occur during pregnancy

A

w/in the first 2 months or 10 weeks of pregnancy

33
Q

characterized by the presence of primitive erthroblasts that produce hemoglobin

A

mesoblastic/megaloblastic phase

34
Q

begins at 5th or 7th gestational weeks

A

hepatic phase

35
Q

what organs contribute to the hematopoietic process of the hepatic phase?

A
  • spleen
  • kidney
  • thymus
  • lymph nodes
36
Q

this phase starts on the 3rd month of fetal life

A

hepatic phase

37
Q

chief site of the hepatic phase

A

liver

38
Q

during the hepatic phase, until how many weeks does the liver retain its activity

A

1-2 weeks after birth

39
Q

what Hemoglobin is characterized during the Hepatic phase

A

HbF (Fetal Hemoglobin)

40
Q

characterized by clusters of developing erythroblasts, granulocytes, and monocytes

A

Hepatic phase

41
Q

chief site of the myeloid/medullary phase

A

BM

42
Q

this starts on the 5th month of fetal life. It increases during the last trimester and remains the chief site at birth

A

myeloid

43
Q

what Hb is produced during the medullary phase

A

HbA

44
Q

M:E ratio reaches adult levels of ___ at 1st week of gestation

A

3:1

45
Q

what types of HbA is producecd during the myeloid phase after first 3 weeks postpartum

A
  • HbA1
  • HbA2
46
Q
A