HEMATOPOIESIS

Question 1

2 types of approaching hematopoiesis

Answer 1

• ontogeny
• phylogeny

Question 2

an approach in hematopoiesis wherein it focuses on embryonic/development POV

Answer 2

ontogeny

Question 3

an approach in hematopoiesis wherein it focuses on evolution POV

Answer 3

phylogeny

Question 4

formation and development of all blood cells

Answer 4

hematopoiesis

Question 5

encompasses the overall interactions of cell renewal, cellular proliferation, differentiation, morphogenesis, functional maturation, and death

Answer 5

hematopoiesis

Question 6

where erythroid precursor is proliferating, differentiating, and nucleating - nucleus is excluded

Answer 6

Erythropoietic island

Question 7

in what organ is the erythropoietic island found?

Answer 7

Bone marrow

Question 8

percentage of nucleated cells in the bone marrow

Answer 8

5-38%

Question 9

percentage of WBCs responsible for granulopoiesis

Answer 9

23-85%

Question 10

percentage of WBCs responsible for lymphopoiesis

Answer 10

1-5%

Question 11

platelet formation

Answer 11

Thrombopoiesis

Question 12

precursor cell

Answer 12

Hemocytoblast

Question 13

3 types of stem cells

Answer 13

• totipotential
• pluripotential
• multipotential

Question 14

stem cell that is more versatile and present few hours after fertilization

Answer 14

totipotential stem cell

Question 15

this stem cell can differentiate into any type of tissue including blood cells

Answer 15

totipotential stem cell

Question 16

this stem cell is the source of developing cell for fetus

Answer 16

totipotential stem cell

Question 17

this stem cell occurs several days after fertilization

Answer 17

pluripotential stem cell

Question 18

it can develop into any tissue except fetus

Answer 18

pluripotential stem cell

Question 19

this stem cell is found in adults but limited to specific type of cells / is localized in 1 organ

Answer 19

multipotential stem cell

Question 20

stem cell is present in the BM and can synthesize cartilage and adipose

Answer 20

multipotential stem cell

Question 21

this stem cell’s function is to proliferate different types of blood cells

Answer 21

multipotential stem cell

Question 22

phases of hematopoiesis under Intrauterine Phase

Answer 22

• mesoblastic/megaloblastic phase
• Hepatic phase
• myeloid/medullary phase

Question 23

connective tissue cells that forms new blood vessels

Answer 23

angioblasts

Question 24

precursor cell

Answer 24

hemocytoblast

Question 25

3 common embryonic hemoglobin and their corresponding chains

Answer 25

*Gower 1 - 2Z and 2E *Gower 2 - 2A and 2E * Portland - 2Z and 2Y

Question 26

this phase of hematopoiesis occurs intravascularly

Answer 26

Mesoblastic

Question 27

begins during the embryonic development in the blood islands of the yolk sac at around the 19th day of gestation

Answer 27

mesoblastic

Question 28

chief site of the megaloblastic phase

Answer 28

Yolk sac

Question 29

Primitive RBC is also known as

Answer 29

Megaloblast of Ehrlich

Question 30

the primitive RBC first develop within the blood island followed by _&_

Answer 30

Leukopoiesis and megakeryopoiesis

Question 31

what are synthesized during the megaloblastic phase

Answer 31

Embryonal Hemoglobins

Question 32

when does the megaloblastic phase occur during pregnancy

Answer 32

w/in the first 2 months or 10 weeks of pregnancy

Question 33

characterized by the presence of primitive erthroblasts that produce hemoglobin

Answer 33

mesoblastic/megaloblastic phase

Question 34

begins at 5th or 7th gestational weeks

Answer 34

hepatic phase

Question 35

what organs contribute to the hematopoietic process of the hepatic phase?

Answer 35

- spleen - kidney - thymus - lymph nodes

Question 36

this phase starts on the 3rd month of fetal life

Answer 36

hepatic phase

Question 37

chief site of the hepatic phase

Answer 37

liver

Question 38

during the hepatic phase, until how many weeks does the liver retain its activity

Answer 38

1-2 weeks after birth

Question 39

what Hemoglobin is characterized during the Hepatic phase

Answer 39

HbF (Fetal Hemoglobin)

Question 40

characterized by clusters of developing erythroblasts, granulocytes, and monocytes

Answer 40

Hepatic phase

Question 41

chief site of the myeloid/medullary phase

Answer 41

BM

Question 42

this starts on the 5th month of fetal life. It increases during the last trimester and remains the chief site at birth

Answer 42

myeloid

Question 43

what Hb is produced during the medullary phase

Answer 43

HbA

Question 44

M:E ratio reaches adult levels of ___ at 1st week of gestation

Answer 44

3:1

Question 45

what types of HbA is producecd during the myeloid phase after first 3 weeks postpartum

Answer 45

- HbA1 - HbA2