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Hematology > Hematopoiesis > Flashcards

Hematopoiesis Flashcards

1
Q
  • Continuous and regulated process
  • blood cell formation
A

Hematopoiesis

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2
Q

Hematopoiesis involved in:

A

Renewal, proliferation, differentiation, and maturation of blood cells

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3
Q

Types of stem cell:

A

Totipotential stem cell, pluripotential stem cell, multipotential cell

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4
Q

Occurs in first few hours of fertilization; embryo to fetus

A

Toti potential

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5
Q

Occurs in several days after fertilizations;develop all cell type except fetus

A

Pluripotential

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6
Q

Derived from pluripotential; found in adults;produce all cell types to form tissues

A

Multipotential

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7
Q

Prenatal / primitive hematopoiesis phases:

A

Mesoblastic, hepatic, medullary / myeloid

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8
Q

Mesoblastic phase site: ( primitive hematopoiesis )

A

Yolk sac

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9
Q
  • Originated in mesodermal
    -Start at 19th day of gestation; ends in 2-3 months of gestation
A

Mesoblastic phase

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10
Q

Mesoblastic phase involved in:

A

Primitive erythroblast (blood islands ) and angioblast ( blood vessels)

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11
Q

Globin chains for hemoglobin (embryonic) -mesoblastic

A

Gower I: 2 epsilon - 2 zeta
Gower ㅍ: 2 alpha - 2 epsilon
Portland: 2 zeta - 2 gamma

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12
Q

Site of pro-definitive hematopoiesis:

A

Aorta-gonad mesonephros

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13
Q

Major regulator of pro definitive hematopoiesis (Aorta-gonad mesonephros)

A

RUNX-1

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14
Q

Partner regulator of RUNX-1

A

CBF-beta

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15
Q

Hepatic phase site:

A

Fetal liver

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16
Q

Extravascular hematopoiesis; lymphoid cells begins to appear

A

Hepatic phase

17
Q

First organ to be developed

A

Thymus

18
Q

Hemoglobin formed in hepatic phase

A

Hgb F: 2 alpha - 2 gamma
Hgb A1: 2 alpha - 2 beta
Hgb A2: 2 alpha - 2 delta

19
Q

Medullary / myeloid phase site:

A

Bore marrow / Red bone marrow

20
Q

M: E ratio

A

3:1 or 4:1

21
Q

Detectable cytokines in medullary phase:

A

Erythropoietin,G-CSF, GM-CSF

22
Q
A

Hematology (3 decks)

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