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Haematology > Hematopoiesis > Flashcards

Hematopoiesis Flashcards

1
Q

List the Aminoglycans

A

Hyaluronic acid
Heparan Sulphate
Chondroitin IV Sulphate
Dermatan

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2
Q

The aminoglycans are secreted by

A

Reticulum/adventitia cells
Marrow stroma cells
Adipose cells
Macrophages

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3
Q

Hematopoietic growth factors

A

GCSF
GMCSF

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4
Q

Which test indicates the proerythroblast has hemoglobin in it

A

Fuelgen’s test

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5
Q

Which RBC precursors have coin circular nucleus

A

Proerythroblast
Basophilic erythroblast
Polychromatic erythroblast

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6
Q

Which rbc precursor has a pyknotic nucleus

A

Orthochromatic erythroblast

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7
Q

Which organ removes the remnants of organelles from the erythrocyte that leaves the HIM environment ?

A

Spleen

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8
Q

The erythrocyte that leaves the BM is referred to as

A

Reticulocyte

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9
Q

The first morphologically identifiable platelet precursor

A

Megakaryoblast

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10
Q

What is the form of maturation of mrgakaryocytes

A

Endonuclear reduplication

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11
Q

Mediators of Platelet adhesion

A

vWf, GpIb receptor

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12
Q

Mediators of platelet aggregation

A

fibrinogen
GpIIb, GpIIIa

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13
Q

Glanzmann’s disease is deficiency of

A

GpIIb, GpIIIa

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14
Q

Deficiency of GpIb

A

Bernard Soulier

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15
Q

Shape of nucleus of myeloblast

A

Ovoid/roundish

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16
Q

In the ……….., there is development of secondary granule

A

Myelocyte

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17
Q

Basophils, neutrophils and oesinophils become differentials at …………. stage of development

A

Myelocyte

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18
Q

At metamyelocytic stage of development of granulocytes, the nucleus is what shaped

A

Bean-shaped

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19
Q

Match the following: basophils, eosinophils, neutrophils to their functions

A

Alarm clocks, Parasitic infections, Bactericidal agents respectively

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20
Q

Examples of opsonins

A

Immunoglobulins and C3b

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21
Q

Macrophages in the brain

A

Glial cells

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22
Q

Macrophages in the BM

A

Histiocytes

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23
Q

Macrophages in the spleen

A

Follicular dendritic cells

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24
Q

Microphages in the skin

A

Langerhan cells

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25
Q

In the kidney, macrophages are

A

Mesanglial cells

26
Q

Macrophages in the lymphatics are

A

veil cells

27
Q

Macrophages in the lungs are

A

Alveolar macrophages

28
Q

The lymphoid committed stem cell is usually identifiable by a cluster of differentiation antigen called

A

CD10+

29
Q

Genes present in all tissues of the body are referred to as

A

GERM LINE INHERITANCE

30
Q

Every B cell in the human body is different because

A

they express different surface Igs

31
Q

The heavy chain of immunoglobulin has

A

Variable region
Diversity region
Joining region
Constant region

32
Q

Regions of the light chain

A

Variable
Constant

33
Q

Number of genes in each heavy chain region

A

V-39-40
D-10
J-6
C-9

34
Q

The kappa or lambda light chain has about (no.of genes in each region)

A

40 variable
2-3 constant

35
Q

One can have how many plasma cells from one virgin B cell

A

128

36
Q

The Pre-T cell is identifiable by the expression of T cell specific cluster of differentiation antigens ………

A

CD 2
CD 3

37
Q

The precortical T cell has which antigens

A

CD1, CD2, CD3

38
Q

The Cortical T cells is which antigens positive

A

CD2
CD3
CD4
CD8

39
Q

Antigens of the medullary T cells

A

CD2
CD3
CD4 or CD8

40
Q

List the T cells that constitute 5% of the T cells in the body

A

T delayed hypersensitivity cells
T suppressor cells
T NK cells

41
Q

The T cell mediates

A

Cellular immunity

42
Q

The T cell possesses what molecule to escape self killing after killing a pathogenic cell

A

Calci-reticulin molecules

43
Q

Cytolytic proteins of the T cell

A

Perforins
Caspases

44
Q

The T cell uses ……… to identify neoantigen on the pathological cell

A

TcR

45
Q

The T cell home is the

A

Paracortex of the Lymph Nodes

46
Q

The B cell home is the

A

Follicular centre of the Lymph Nodes
(where it undergoes further development)

47
Q

You only have cleaved cells in the development of which cells

A

B cells (only non cleaved cells in T)

48
Q

T immunoblast does not mature any further T/F

A

T

49
Q

Function of T delayed hyper sensitivity cells

A

Supply interferon gamma to aid monocyte-macrophage functions against chronic bacterial infections and fungal illnesses

50
Q

Function of T suppressor cells

A

Limit immune hyperactivity

51
Q

Function of T Natural Killer cells

A

Cytotic kill on Cancerous/ Mitotic cells

52
Q

Function of Cytotoxic T cells

A

aka CD8+
Cytotic kill on VIRALLY infected cells

53
Q

Function of macrophages

A

Immune response against bacterial, fungal and particulate agents

54
Q

Which cell is regarded as the Pivotal Cell of Immunity

A

CD4+ / Helper T-cells

55
Q

3 types of helper T cells

A

TH 1
TH 2
TH 17

56
Q

The TH-2 cell is referred to as

A

The T-regulatory cell

57
Q

Function of TH 1 cell

A

Effector cell that cytolizes other cells

58
Q

Any human cell expressing CD4 molecule is infectable by

A

HIV

59
Q

Goals of anti-retro viral therapy

A

Virologic goal
Immunological goal
Clinical goal
Epidemiological goal

60
Q

Oxygen Tension of Blood is

A

Amount of O2 present in 100ml of blood

61
Q

With decrease in Hb concentration, what happens to O2 Tension

A

Reduces

Haematology (3 decks)

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