Hematopoiesis

Question 1

The earliest visually recognized erythrocyte precursors in the bone marrow.

A. Basophilic Erythroblast
B. Orthochromic Erythroblast
C. Pronormoblast
D. Polychromatophilic Erythroblast

Answer 1

C. Pronormoblast

Question 2

Embryonic form of hemoglobin with 2 alpha chains and 2 epsilon chains.

A. Gower I
B. Gower II
C. Portland

Answer 2

B. Gower II

Question 3

Yolk sac hematopoiesis differs from hematopoiesis that occurs later in the fetus and the adult in that it occurs intravascularly, or within developing blood vessels. Primitive erythroblast are important in early embryogenesis to produce hemoglobin (Gower I, Gower II, Portland).

A. All statements are true.
B. All statements are false.
C. The first statement is true while the second statement is false.
D. The first statement is false while the second statement is true.

Answer 3

A. All statements are true.

Question 4

The process of replacing the active marrow by adipocytes (yellow marrow) during development.

A. Regression
B. Retrogression
C. Repercussion
D. Reversion

Answer 4

B. Retrogression

Question 5

Which one of the following morphologic changes occurs during normal blood cell maturation:

A. Increase in cell diameter
B. Development of cytoplasm basophilia
C. Condensation of nuclear chromatin
D. Appearance of nucleoli

Answer 5

C. Condensation of nuclear chromatin

Question 6

Burst-forming unit-erythroid (BFU-E) is the earliest identifiable colony of RBCs which rises from

A. CFU-E
B. TPO
C. GM-CSF
D. CFU-GEMM

Answer 6

D. CFU-GEMM

Question 7

This type of growth factor produced from the kidneys is used to treat anemia associated with kidney disease:

A. IL-2
B. EPO
C. TPO
D. GM-CSF

Answer 7

B. EPO

Question 8

Main site of production of TPO.

A. Spleen
B. Thymus
C. Kidney
D. Liver

Answer 8

D. Liver

Question 9

The preferred site for collection of active bone marrow is:

A. Iliac crest
B. Sternum
C. Vertebrae
D. Ribs

Answer 9

A. Iliac crest

Question 10

Culling is the process wherein the splenic macrophages remove inclusions or damaged surface membrane from the circulating RBCs. Pitting occurs when the spleen phagocytizes the senescent or abnormal RBCs with subsequent degradation of cell organelles.

A. All statements are true.
B. All statements are false.
C. The first statement is true while the second statement is false.
D. The first statement is false while the second statement is true.

Answer 10

B. All statements are false.

Question 11

Fetal forms of hemoglobin with 2 alpha chains and 2 delta chains.

A. HbA
B. HbA2
C. HbF

Answer 11

A. HbA

Question 12

Normal Myeloid:Erythroid ratio

A. 1:2 to 1:4
B. 3:1 to 5:1
C. 2:1 to 4:1

Answer 12

C. 2:1 to 4:1

Question 13

It suggest that all blood cells are derived from a single progenitor stem cell called a pluripotential stem cell.

A. Polyphyletic Theory
B. Monophyletic Theory

Answer 13

B. Monophyletic Theory

Question 14

During this phase, the yolk sac discontinues its role and the fetal liver becomes active.

A. Mesoblastic phase
B. Hepatic phase
C. Medullary phase
D. Myeloid phase

Answer 14

B. Hepatic phase

Question 15

The first cell the human body produce is ______.

A. Leukocyte
B. Platelet
C. Pronormoblast
D. Erythrocyte

Answer 15

D. Erythrocyte