Hematopoesis Defintions 1

Question 1

Burst Forming Unit (BFU)

Answer 1

cell culture colony of a large cell cluster (100-10000 cells) that contain many immature and mature cells too

Question 2

Colony Forming Unit (CFU)

Answer 2

small cell cluster (8-50 cells) that forms when a mononuclear bone marrow cell is placed in cell culture

Question 3

Erythropoiesis

Answer 3

development and maturation of red cell precursors. Recognizable stages: rubriblast, prorubricyte, rubricyte, metarubricyte, polychromatophilic erythrocyte, erythrocyte

Question 4

Erythropoietin (Epo)

Answer 4

produced mostly in the kidney in response to hypoxemia and will stimulate primarily CFU-E and to a lesser extent BFU-E to induce proliferation and differentiation of erythroid progenitors

Question 5

Flt3 Ligand (FL)

Answer 5

hematopoietic cytokine produced by bone marrow fribroblast and T- lymphocytes exert stimulatory effect on hematopoioetic stem cells. This GF capable of promoting growth of granuloycytic, monocytic, and lymphoid progenitor cells but not erythroid progenitors

Question 6

Granulopoiesis

Answer 6

development and maturation of precursors of neutrophil, eosinophils, and basophils. Recognizable stage: myeloblast, progranulocyte, myelocyte, metamyelocyte, band, segmented

Question 7

Granulocyte-Macrophage-Colony-Stimulating Factor (GM-CSF)

Answer 7

GF important for intermediate multilineage progenitors. Released from T lymphocytes, macrophages, endothelial cells, and fibroblasts in response to other cytokines and endotoxin to act upon CFU-GM and CFU-Eo to produce mature monocytes or neutrophils and eosinophils

Question 8

Hematopoiesis

Answer 8

production of blood both lymphoid and myeloid (nonlymphoid)

Question 9

Interleukin 3 (IL-3)

Answer 9

GF important for induction of every derivative from the hematopoietic stem cell except lymphoid progenitors

Question 10

Nurse cell

Answer 10

central macrophage w/in an erythroid island that provides nutrients to the maturing erythroid precursors adhernet to its cell surface, part. through rhopheocytosis

Question 11

Pluripotential stem cell

Answer 11

progenitor in the bone marrow that gives rise to multiple lineages of lymphoid and myeloid cells

Question 12

Reticulocyte

Answer 12

polychromatophilic stage of erythrocyte that still contains ribosomal material which can be identified by new methylene blue stain which forms an artifact of network or reticulum w/in the cytoplasm

Question 13

Stem Cell Factor

Answer 13

GF important for early prognitors. known as C-kit ligand. Produced from marrow stromal cells and fetal tissues and targets the hematopoietic stem cell to enter the cell cycle. Helps increase size and number of colonies.Promote growth or erythroid and megakaryocytic progenitors and mast cells.

Question 14

Thrombopoiesis

Answer 14

development and maturation of platelet precursors

Recognizable stages: megakaryoblast, promegakaryocyte, basophilic megakaryocyte, mature megakaryocyte, and platelet

Question 15

Thrombopoietin (Tpo)

Answer 15

Produced by endothelial cells and fibroblasts to act upon BFU-Mega and CFU-Mega to differentiate megakaryocyteic progenitors and cause megakaryocytes to enlarge and fragment into platelets