Hematopathology Flashcards
Reactive lymphadenitis
- all show intact (though altered) architecture, with preserved B and T cell zones, preserved sinuses and capsules
- most: reactive follicular hyperplasia
- specifics: Cat scratch, IM
Histo of Cat scratch disease
- Stellate microabscesses (see neutrophils in middle of granuloma)
- Follicular hyperplasia
- caused by Bartonella henselae
Histo of Infectious mononucleosis
- Expansion of paracortex/ interfollicular area (T cell zone)
- “Moth-eaten” appearance
- Scattered large immunoblasts
- caused by Epstein Barr Virus
Leukemoid reaction
Setting of severe infection or tumor (exaggeration of normal leukocytosis of infection)
- elevated neutrophils, circulating immature myeloid precursors, < 5% blasts
Leukemia
marrow, blood based disorder - any hematopoietic lineage
Lymphoma
lymph node, lymphoid tissue disorder - lympoid lineage only
Lymphoid leukemia
T, B, NK cell origin
Myeloid leukemia
any other cell origin - granulocyte, monocyte, eos, basos, erythrocyte, megakaryocyte
Myelodysplastic disorders
peripheral cytopenias (usually anemia)
- hypercellular marrow but with ineffective hematopoiesis
- dysplastic features
Myeloproliferative disorders
increased peripheral counts
- hypercellular, proliferating marrow
- usually no dysplasia
Plasma cell neoplasm/ multiple myeloma
normal peripheral counts
- hypercellular marrow
- prod of monoclonal Ig - M spike
Non-Hodgkin lymphomas (NHL)
predominant cell population is neoplastic
- monomorphic appearance
70% of lymphomas
divide into B and T cell NHLs (rarely NK)
- subdivide into percursor (immature) and peripheral (mature)
Hodgkin Lymphoma (HL)
tumor cells are rare. predominant cell population is reactive
- polymorphic appearance
30% of lymphomas
Chronic leukemia
differentiated cells predominate
onset is insidious, slow
long survival
Acute leukemia
blast cells (immature cells w/ features of hematopoietic SC) predominate onset is abrupt rapid course (3-4 mo) if untreated
