Hematology- Red Blood Cells Flashcards
Where does hematopoiesis occur in a fetus?
Liver
Spleen
Where does hematopoiesis occur in a newborn animal?
Red bone marrow
Where does hematopoiesis occur in an adult?
Red Bone marrow
sternum, skull, vertebral column, proximal ends of femur, pelvis, ribs
Where do all blood cells come from?
Pluripotential or Multipotential stem cells
Where is EPO produced?
Kidneys (peritubular interstitial cells)
What is the effect that hypoxia has on erythropoiesis?
Oxygen is lowered
Kidneys slow/stop
No EPO
Anemia
Maturation order of RBC
Rubriblast Prorubricyte Rubricyte-Basophilic and polychromatophilic Metarubricyte Reticulocyte
What does a mature RBC contain?
Water
Hemoglobin
Other structural elements
What does erythropoietin control?
It controls the rate of erythropoiesis
How do mature RBCs appear under a microscope?
Non-nucleated, biconcave discs with a control zone that is thinner and appears lighter.
What do mature RBCs use for energy?
Glucose from plasma
What makes a mature RBC stain red?
Hemoglobin
What shape are the RBCs in the camelid species?
Elliptical or oval RBCs
What shape are the RBCs in deer?
Sickle-shaped RBCs
What shape are the RBCs in birds, fish, amphibians and reptiles?
Elliptical that are nucleated
What is the first phase of growth in a platelet?
Megakaryocyte
How long does thrombopoiesis typically take?
7 days to complete
Which of the WBCs are granulocytes?
Basophils
Eosinophils
Neutrophils
Which of the WBCs are agranulocytes?
Lymphocytes
Monocytes
What is whole blood composed of?
93% fluids and tissues
7% blood
What are the whole blood percentages based on?
Body weight
What is the percentage of plasma in whole blood?
55%
What is the percentage of formed elements in whole blood?
45%
What are the percentages of plasma and formed elements based on?
Volume
What is plasma made up of?
7% protein
91% water
Other cells
What is plasma composed of?
Albumin
Fibrinogen
Globulins
What are in other cells in plasma?
Ions Water products Nutrients Gases Hormones
What type of connective tissue is blood?
Connective
What is contained within the peripheral blood?
Oxygen
Nutrients
Waste materials