Hematology- Red Blood Cells Flashcards

1
Q

Where does hematopoiesis occur in a fetus?

A

Liver

Spleen

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2
Q

Where does hematopoiesis occur in a newborn animal?

A

Red bone marrow

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3
Q

Where does hematopoiesis occur in an adult?

A

Red Bone marrow

sternum, skull, vertebral column, proximal ends of femur, pelvis, ribs

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4
Q

Where do all blood cells come from?

A

Pluripotential or Multipotential stem cells

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5
Q

Where is EPO produced?

A

Kidneys (peritubular interstitial cells)

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6
Q

What is the effect that hypoxia has on erythropoiesis?

A

Oxygen is lowered
Kidneys slow/stop
No EPO
Anemia

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7
Q

Maturation order of RBC

A
Rubriblast
Prorubricyte
Rubricyte-Basophilic and polychromatophilic
Metarubricyte
Reticulocyte
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8
Q

What does a mature RBC contain?

A

Water
Hemoglobin
Other structural elements

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9
Q

What does erythropoietin control?

A

It controls the rate of erythropoiesis

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10
Q

How do mature RBCs appear under a microscope?

A

Non-nucleated, biconcave discs with a control zone that is thinner and appears lighter.

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11
Q

What do mature RBCs use for energy?

A

Glucose from plasma

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12
Q

What makes a mature RBC stain red?

A

Hemoglobin

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13
Q

What shape are the RBCs in the camelid species?

A

Elliptical or oval RBCs

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14
Q

What shape are the RBCs in deer?

A

Sickle-shaped RBCs

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15
Q

What shape are the RBCs in birds, fish, amphibians and reptiles?

A

Elliptical that are nucleated

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16
Q

What is the first phase of growth in a platelet?

A

Megakaryocyte

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17
Q

How long does thrombopoiesis typically take?

A

7 days to complete

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18
Q

Which of the WBCs are granulocytes?

A

Basophils
Eosinophils
Neutrophils

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19
Q

Which of the WBCs are agranulocytes?

A

Lymphocytes

Monocytes

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20
Q

What is whole blood composed of?

A

93% fluids and tissues

7% blood

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21
Q

What are the whole blood percentages based on?

A

Body weight

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22
Q

What is the percentage of plasma in whole blood?

A

55%

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23
Q

What is the percentage of formed elements in whole blood?

A

45%

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24
Q

What are the percentages of plasma and formed elements based on?

A

Volume

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25
Q

What is plasma made up of?

A

7% protein
91% water
Other cells

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26
Q

What is plasma composed of?

A

Albumin
Fibrinogen
Globulins

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27
Q

What are in other cells in plasma?

A
Ions
Water products
Nutrients
Gases
Hormones
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28
Q

What type of connective tissue is blood?

A

Connective

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29
Q

What is contained within the peripheral blood?

A

Oxygen
Nutrients
Waste materials

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30
Q

What is the liquid portion of blood?

A

Plasma

31
Q

What is in plasma?

A

Water

Various solubles

32
Q

What does the cellular portion of blood contain?

A

Red Blood Cells- erythrocytes
Platelets- thrombocytes
White blood cells- leukocytes

33
Q

Where do blood samples come from?

A

Peripheral blood

34
Q

Hemolysis

A

Destruction of erythrocytes

35
Q

Erythrocyte

A

Red blood cell

36
Q

Pyknotic

A

More dense

37
Q

Bilirubin

A

Insoluble pigment derived from the breakdown of hemoglobin

38
Q

Albumin

A

A group of plasma proteins that comprises the majority of protein in plasma

39
Q

Hemoglobin

A

Oxygen-carrying pigment of erythrocytes

40
Q

Leukocyte

A

White blood cell

41
Q

Thrombocyte

A

Platelets

42
Q

Plasma

A

The fluid portion of blood

43
Q

Serum

A

The fluid portion of blood after is has clotted, does not contain coagulation proteins

44
Q

Erythropoiesis

A

The production of erythrocytes

45
Q

Anticoagulant

A

Any substance that inhibits or prevents clotting

46
Q

Basophilic stippling

A

Erythrocytes that are characterized by small, blue-staining granules.

47
Q

Hematopoiesis

A

The production of blood cells and platelets

48
Q

Howell-Jolly Bodies

A

Basophilic inclusions of young erythrocytes that represent nuclear remnants

49
Q

What are the formed elements within the blood?

A

Platelets
Leukocytes
Erythrocytes

50
Q

How many platelets are in the blood?

A

200-500 thousand

51
Q

How many leukocytes are in the blood?

A

6-17 thousand

52
Q

What are the types of leukocytes?

A
Neutrophil
Lymphocytes
Monocyte
Eosinophil
Basophil
53
Q

How many erythrocytes are in blood?

A

5.5-8.5 million

54
Q

What are the 4 levels of a PCV after it’s been centrifuged?

A

Plasma
Serum
Packed Cell Volume
Clay plug

55
Q

What color is a hemolyzed plasma sample?

A

Red

56
Q

What color is a Lipemic plasma sample?

A

White

57
Q

What color is an Icteric plasma sample?

A

Yellow

58
Q

What color is a normal plasma sample?

A

Normal

59
Q

What are the three main functions of blood?

A

Transportation
Regulation
Defense

60
Q

What do erythrocytes contain?

A

Hemoglobin

61
Q

What is hemoglobin made up of and how many oxygen molecules does it contain?

A

Made up of 4 heme units and each unit contains 1 oxygen molecule.

62
Q

How many oxygen molecules can one hemoglobin molecule contain?

A

4 oxygen molecules

63
Q

HbE

A

Embryonic hemoglobin

64
Q

HbF

A

Fetal hemoglobin

65
Q

Hb

A

Adult hemoglobin

66
Q

What is the average lifespan of an RBC in a dog?

A

120 days

67
Q

What is the average lifespan of an RBC in a cat?

A

68 days

68
Q

What percentage of hemolysis is extravascular?

A

90%

69
Q

What percentage of hemolysis is intravascular?

A

10%

70
Q

What color will acidic structures stain?

A

Red

71
Q

What color will alkaline structures stain?

A

Blue

72
Q

What is supervital stain?

A

IT’s a type of stain that is used when components of a cell need to be visualized, but cannot be picked up by the Romanousky-type stains.

73
Q

What kind of stain is Diff-Quick?

A

Modified Wright’s stain

74
Q

What kind of unique reticulocytes does a cat have?

A

Punctate