Hematology Blood Cell Alterations

Question 1

All WBCs in the circulation blood should be ________.

Answer 1

mature

Question 2

What observations are noted to differentiate immature WBCs under a microscope?

Answer 2

1. Size
2. Cellular Structure (presence of granules, changes in nucleoli, chromatin, or nucleus)
3. Staining Properties

Question 3

In immature WBCs:

1. The nucleus is ________.
2. Chromatin is ________ and ________.
3. ________ may be present.

Answer 3

1. round
2. fine and lacy
3. Nucleoli

Question 4

Along with size, shape, and color/staining reaction what additional morphological examinations of RBCs must be observed?

Answer 4

1. Structure and inclusions of the cell membrane
2. Artifacts and abnormal distribution patterns
3. Nucleated red cells

Question 5

Red cells are described as ________ when they contain the normal amount of hemoglobin.

Answer 5

Normochromic

Question 6

What is the term which refers to the color in the middle of an RBC?

Answer 6

Central Pallor

Question 7

The diameter of the central pallor is less than ________ the diameter of a normochromic erythrocyte.

Answer 7

⅓

Question 8

RBCs that are very pale and show an increased area of central pallor are termed ________.

Answer 8

Hypochromic

Question 9

What are two types of red cells that appear to be “hyperchromatic” due to the increased uptake of hemoglobin?

Answer 9

1. Macrocyte (thicker cellular membrane)
2. Spherocyte (round cell without a biconcave depression)

Question 10

What is the descriptive term which refers to RBCs that show a faint blue or blue-orange color with Wright’s stain?

Answer 10

Polychromasia

Question 11

________ is a general term indicating an increased variation in the shape of RBC’s.

Answer 11

Poikilocytosis

Question 12

These RBCs are oval, or egg shaped, showing varying degrees of elliptical shaping to almost a cylindrical form.

Answer 12

Elliptocytes and Ovalocytes

Question 13

These cells are typically narrow with pointed ends. They may also vary from crescent shaped to bipolar spiculated forms, to cells with long irregular spicules.

Answer 13

Sickle Cell (Depranocyte)

Question 14

These cells are the results of the genetic condition in which abnormal hemoglobin (Hb S) is present in a homozygous state in RBC‘s.

Answer 14

Sickle Cells (Drepanocytes)

Question 15

What type of cells are present with the following: Hb SS, Hb SC, Hg B-thalassemia.

Answer 15

Sickle Cells (Drepanocytes)

Question 16

These cells show a peripheral ring of hemoglobin, an area of pallor or clearing, and then a central area of hemoglobin.

Answer 16

Target Cells (Codocytes)

Question 17

The Target Cell circulates as a ________ shaped cell but takes on the ________ shape when dried on a slide for morphilogical examination.

Answer 17

bell, target

Question 18

These RBCs are not biconcave; instead, they appear round or spherical because of the loss of a portion of the cell membrane.

Answer 18

Spherocytes

Question 19

These cells show a slitlike or mouthlike center, rather than round area of central pallor on the blood film. They are often found in chronic liver disease.

Answer 19

Stomatocyte