Hematology - Anemia Flashcards
Low # of mature RBCs
Normochromic
Normocytic
Renal failure
Low EPO
Renal failure
High ferritin
Low transferin
Low TIBC
Low Fe
Anemia of Chronic Disease
Pancytopenia
Aplastic anemia (cancer)
Heinz bodies
Oxydative stress
G6PDH deficiency anemia
Low NAPDH
G6PDH deficiency anemia
Low spectrin
Low ankorin
Hereditary spherocytosis
What does pernicious anemia mean
Low B12/folate
What does B12 and folate do in the production of RBCs?
Condenses DNA
Is pernicious anema microcytic or macrocytic and why?
Macrocytic because B12 and Folate are not there to condense DNA (to make RBCs smaller) so the RBCs are bigger
What stores iron
Ferritin
What transports iron
Transferin
What controls release of iron
Hepcidin
High hepcidin = ______ serum iron
High
What form of Fe causes fenton rxns and increased ROSs
Fe3+
Name the lytic anemias
heredetary spherocytosis
sickle cell anemia
G6PDH defeciency
Lytic anemias can cause what?
Splenomegaly
What kind of Hgb do sickle cell pts have
HbS
What can low PO2 cause in sicle cell disease
HbS polymerization causes them to get stuck in microvasculature causing infarct
Which type of thalassemia is more severe?
Beta thalassemia
Causing hemolysis of hgb
Beta thalassemia
Deficiency of hgb (type of thalassemia)
Alpha thalassemia
MCV for macrocytic anemias
MCV >90
MCV for microcytic anemias
MCV <90
Increased AST/ALT, Ferritin, Fe
hemochromatosis
Combs test is for which anemia
Autoimmune premature destruction of RBCs anemia
