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AFN Pathophysiology > Hematology - Anemia > Flashcards

Hematology - Anemia Flashcards

1
Q

Low # of mature RBCs
Normochromic
Normocytic

A

Renal failure

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2
Q

Low EPO

A

Renal failure

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3
Q

High ferritin
Low transferin
Low TIBC
Low Fe

A

Anemia of Chronic Disease

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4
Q

Pancytopenia

A

Aplastic anemia (cancer)

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5
Q

Heinz bodies
Oxydative stress

A

G6PDH deficiency anemia

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6
Q

Low NAPDH

A

G6PDH deficiency anemia

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7
Q

Low spectrin
Low ankorin

A

Hereditary spherocytosis

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8
Q

What does pernicious anemia mean

A

Low B12/folate

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9
Q

What does B12 and folate do in the production of RBCs?

A

Condenses DNA

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10
Q

Is pernicious anema microcytic or macrocytic and why?

A

Macrocytic because B12 and Folate are not there to condense DNA (to make RBCs smaller) so the RBCs are bigger

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11
Q

What stores iron

A

Ferritin

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12
Q

What transports iron

A

Transferin

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13
Q

What controls release of iron

A

Hepcidin

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14
Q

High hepcidin = ______ serum iron

A

High

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15
Q

What form of Fe causes fenton rxns and increased ROSs

A

Fe3+

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16
Q

Name the lytic anemias

A

heredetary spherocytosis
sickle cell anemia
G6PDH defeciency

17
Q

Lytic anemias can cause what?

A

Splenomegaly

18
Q

What kind of Hgb do sickle cell pts have

A

HbS

19
Q

What can low PO2 cause in sicle cell disease

A

HbS polymerization causes them to get stuck in microvasculature causing infarct

20
Q

Which type of thalassemia is more severe?

A

Beta thalassemia

21
Q

Causing hemolysis of hgb

A

Beta thalassemia

22
Q

Deficiency of hgb (type of thalassemia)

A

Alpha thalassemia

23
Q

MCV for macrocytic anemias

A

MCV >90

24
Q

MCV for microcytic anemias

A

MCV <90

25
Q

Increased AST/ALT, Ferritin, Fe

A

hemochromatosis

26
Q

Combs test is for which anemia

A

Autoimmune premature destruction of RBCs anemia

AFN Pathophysiology (6 decks)

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