Hematology and Oncology

Question 1

Absolute Eosinophilia Count

Answer 1

Greater than 500/uL

Question 2

Red Flag signs of Eosinophila

Answer 2

AEC >1500/uL
presence of end organ damage

Question 3

1. Absolute Basophilia Count
2. In the absence of infection, what should you be your workup heading to?

Answer 3

1. Greater than 200/uL
2. myeloproliferative neoplasms

Question 4

1. Absolute monocytosis count
2. Usual etiology of monocytosis?
3. Absolute monocytopenia count

Answer 4

1. Greater than 800/uL
2. primary hematologic disorders
3. <400/uL

Question 5

Absolute neutropenia count

Answer 5

<1500/uL

Question 6

Absolute lymphocyte count for lymphopenia

Answer 6

<1000/uL

Question 7

1. accounts for 90% of adult leukemias
2. accounts for children leukemias

Answer 7

1. AML
2. ALL

Question 8

1. CML treatment
2. CML usually derived from (?) translocation?
3. Indolent malignancy of mature B cells

Answer 8

1. tyrosine kinase inhibitor
2. Philadelphia Chromosome (t9:22)
3. CLL

Question 9

What are your B symptoms?

Answer 9

10% weight loss
fever
night sweats

Question 10

Diagnostic tests that confirms specific subtypes of leukemia

Answer 10

Bone marrow studies

Question 11

Treatment for CLL?

Answer 11

BTK inhibitors, P13K delta inhibitors, BCL2 inhibitors

Question 12

Critical component of managing cancer

Answer 12

assessment of treatment response

Question 13

Most common cancer side effect treatments (4)

Answer 13

nausea
vomiting
myelosuppresbsion
febrile neutropenia

Question 14

Most common cancer side effect treatments (4)

Answer 14

nausea
vomiting
myelosuppression
febrile neutropenia

Question 15

severe reduction in venous return form head, neck and upper extremity

Answer 15

Superior Vena Cava Syndrome

Question 16

Type of cancer that accounts majority of SVC syndrome

Answer 16

Lung cancer - elderlies
Lymphoma - young adults

Question 17

True or False:
The prognosis of SVC syndrome relates to the underlying cause instead of caval obstruction

Answer 17

True

Question 18

Treatment of SVC syndrome

Answer 18

Symptomatic: diuretics, O2 supplementation, low salt diet
Palliative: Stents

Question 19

Tingling or electric sensation down the back and upper/lower limbs upon flexing or extending the neck

Answer 19

Lhermitte’s sign

Question 20

May be an early sign of cord compression

Answer 20

Lhermitte’s sign

Question 21

Compression of the spinal cord by an extradural tumor mass

Answer 21

Malignant spinal cord compression

Question 22

Most common symptom of malignant spinal cord compression

Answer 22

localized back pain and tenderness exacerbated by movement, and coughing/sneezing

Question 23

Signs of Tumor Lysis Syndrome (4)

Answer 23

Hyperuricemia
Hypocalcemia
Hyperphosphatemia
Hyperkalemia

Question 24

When do you start hemodialysis in tumor lysis syndrome? Please indicate labs:

Answer 24

Serum K >6
UA >10
Crea >10
Phosphate >10
or increasing symptomatic hypocalcemia

Question 25

Signs of Hypocalcemia

Answer 25

“CATS”
C - convulsions
A - arrythmias
T - tetany
S - spasms and stridor

Question 26

Standard preventive approach of tumor lysis syndrome

Answer 26

Hydration
Allopurinol