Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MLS hematology 2020 > Hematology > Flashcards

Hematology Flashcards

1
Q

bite cells, blister cells, heinz bodies (denatured hgb, super vital stain) what disease process is this?

A

G6PD deficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Antibodies attack ADAMTS13 so that it loses its function and big, uncut vWB factor (ULVWM) clogs the microvasculature. This causes clotting issues and sheer stress.

A

thrombotic thrombocytopenic purpura (TTP)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What globulin chains do adults have?

A

2- alpha

2- beta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What globulin chains does the fetus have?

A

2- alpha

2- gamma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Rare disorder of the erythrocytes membrane. The defect makes the cell abnormally sensitive to lysis of complement.

A

PNH (paroxysmal nocturnal hemoglobinuria)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Large platelets, decreased plts, Dohle bodies in segs.

A

May-Hagglin anomoly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Large purpulish granules in cytoplasm incompletely degraded mucopolysaccharides.

A

Alder-Riley

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Causes recurrent bacterial infections and the WBCs have bluish-gray inclusions.

A

Chediak-Higashi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Condition where there is a chronic sustained leukocytosis and all stages of cell maturation are seen?

A

Myeloproliferative Disorders

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

CD13 and CD33

A

Myeloid cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

CD41 and CD61

A

Megakaryoblasts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Calculate MCV

A

HCT/RBC x 10

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Calculate MCH

A

HGB/RBC x 10

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Calculate MCHC

A

HB/HCT x 100

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What cells is increased in bacterial infections?

A

Neutrophil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What cell is increased in viral infections?

A

Lymphocyte

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Calculate WBC

A

of cells counted x (1/0.9) x dilution factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Calculate hematocrit

A

hgb/rbc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

t(15:17)

A

APL (acute promyelocytic leukemia)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

t(9;22) philadelphia chromosome

bcr/abl fusion gene

A

CML (chronic lymphocytic leukemia)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

t(8;21)

A

AML

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Expected RBC indicies in a patient with rouleaux?

A

RBC decreased

MCV, MCHC increased

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Blasts that stain with myeloperoxidase and specific esterase are in what lineage?

A

myleocytic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Retic reference range?

A

0.5-1.5%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

IDA, Chronic disease/inflammation, lead poisoning and Thalassemia Trait fall in what anemia classification?

A

Microcytic/hypochromic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

B12, pernicous anemia and malabsorption/dietary, folate deficiency, liver disease/alcholism fall under what anemia classification?

A

Macrocytic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

This macrocytic anemia with have decrease B12, oval macrocytes, hypersegemented polys, H-J bodies?

A

B12 deficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

If a paient is suspected to have PA what test should be run?

A

Anti-IF factor (positive), MMA (methymalonic acid), homocystine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Antibody mediated anemia showing nornmocytic/normchromic anemia include what disease processes?

A

PCH
Cold agglutinin Disease
Warm autoimmune hemolytic anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Anemia caused by these diseases is due to a membrane defect:

A

Herediatry spherocytosis
Hereditary Elliptocytosis
PNH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Anemia due to an enzyme deficiency:

A

G6PD (heinz bodies)

PK (no heinz bodies)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Anemia due to decreased production of EPO or loss, dry tap during bone marrow, hypocellular bone marrow, decreased retics and pancytopenia:

A

Aplastic anemia
Acute blood loss
Chronic renal failure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

A cytokine produced that increases production of platelets?

A

TPO

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Patients with this genetic disorder are sometimes partial albino:

A

Chediak Higashi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

What represents the biochemical composition of pappenheimer bodies?

A

Iron

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

H-J bodies are composed of what?

37
Q

Basophilic stippling is composed of what?

38
Q

Pappenheimer bodies are composed of what?

39
Q

Heinz bodies are composed of what?

A

Denatured Hgb

40
Q

Cabot rings are composed of what?

A

remnants of mitotic spindle

41
Q

A hypocellular bone marrow has an M;E ratio of 5:1 what does this indicate?

A

Decreased erythropoiesis

42
Q

In a hypercellular bone marrow what would be increased?

A

erythropoiesis

43
Q

An increased LAP is indicative of what?

A

leukemoid reaction

44
Q

A decreased LAP is indicative of what?

45
Q

This leukemia will have lymphocytes with cytoplasmic projections, is TRAP positive and is CD 103, CD 11 and CD 25 positive

A

hairy cell leukemia

46
Q

This leukemia has increased mylocytic cell precursors from blast to mature neutrophil:

47
Q

This leukemia is classified by >20% blasts present:

48
Q

A physician orders interphase FISH to detect the BCR/ABL1 fusion protein. The results are positive. What is the karyotype likely to detect?

A

t(9;22) CML

49
Q

CD2, CD3, CD5, CD7 are what cell lineage?

A

T-cell lineage

50
Q

CD10 (calla), CD19, CD22 are what cell lineage?

A

B-cell lineage

51
Q

CD13 and CD33 are what cell lineage?

A

myeloid lineage

52
Q

JAK 2 mutation is are marker for what?

A

PV (polycythemia vera)

53
Q

Myelocytes with auer rods seen is representative of what leukemia?

A

APL (acute promyelocytic leukemia)

54
Q

Refractory anemia

A

<5% blasts present

55
Q

Refractory anemia with sideroblasts

A

<5% blasts with ringed sideroblasts

56
Q

Refractory anemial with excess blasts

A

5-20% blasts

57
Q

Lytic bone lesions, sheets of plasma cells in the BM, Rouleaux with red cells, serum protein monoclonal spike and urinary excretion of bence jones protein (IgG) is indicative of what disease process?

A

Multiple myeloma

58
Q

Normal bone scan, increased serum viscosity and increased IgM is indicative of what disease process?

A

Waldenstrom macroglobulinemia

59
Q

The Reed Sternberg cell is associated with what disease process?

A

Hodgkin lymphoma

60
Q

Increased TIBC is associated with what?

61
Q

Increased Ferritin is seen in what disease processes?

A

Thalassemia, Anemia of chronic disease (inflammation)

62
Q

What disease process will you see an increased Hg F?

A

Beta thalassemia

63
Q

What disease process will you see an decreased Hg A

A

Alpha thalassemia

64
Q

Heinz bodies are seen in what disease processes?

A

G6PD Deficiency
Thalassemia
Unstable hemoglobins

65
Q

Mciroangiopathic hemolytic anemai is characterized by:

A

Schitocytes and basophilic stippling

66
Q

In PV what parameter would be increased?

67
Q

Essential thrombocythemia (ET) is characterized by an increase in what?

A

Platelets >1 million

68
Q

What is the normal myeloid to erythroid ratio?

69
Q

Hemoglobin H disease is associated with which thalassemia?

A

Alpha Thalasemmia

70
Q

RDW range?

71
Q

Adults reference range for Hg A?

72
Q

Adult reference range for Hg A2?

73
Q

Adult reference range for Hg F?

74
Q

Which cells stain strongly with myeloperoxidase?

A

neutrophils

75
Q

A hypercellular bone marrow has an M:E ratio of 10:1. This indicates:

A

Increased leukopoiesis

76
Q

In which hematological disorder would you expect to encounter an increased total binding capacity (TIBC)?

77
Q

Serum iron normal
TIBC decreased
Serum ferritin increased

A

anemia of chronic disease

78
Q

In which disorder are increases in Hgb A2 and F seen?

A

Beta Thalassemia

79
Q

The most common type of acute leukemia in children?

80
Q

No detectable B cells in the bone marrow but a normal amount of T cells. It is X linked.

A

Bruton’s X-linked agammaglobulinemia

81
Q

Infants with sickle cell disease typically do not become symptomatic until 6 months of age. How do you explain this?

A

The concentration of Hemoglobin F predominates over Hgb S.

82
Q

Severe combined immunodeficiency exhibits:

A

decreased or dysfunctional T and B cells

83
Q

t(15;17)

84
Q

the major iron storage compound?

85
Q

A decreased value of this indicated no iron stores?

86
Q

Oval macrocytes, decreased B12 and positive Intrinsic Factor antibodies (IF) are indicative of what disease?

A

Pernicious Anemia (PA)

87
Q

What is the molecular structure of Hgb F?

A

2 alpha

2 gamma

88
Q

What is the molecular structure of Hgb A?

>95% of adult hemoglobin

A

2 alpha

2 beta

89
Q

What is the molecular structure of Hgb A2?

A

2 alpha

2 delta

MLS hematology 2020 (1 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions