Hematology Flashcards

1
Q

Labs in DIC

A
Thrombocytopenia 
High PT and PTT
Low fibrinogen
Raised FDP and D-dimer
Hemolytic anemia
Reduced protein C and S and antithrombin
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2
Q

The most important aspect in treating DIC?

Supportive by?

A

Treat the underlying cause (usually sepsis)

Supportive by FFP, cryoprecipitate and platelets)

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3
Q

Pathophysiology of DIC?

A

Purpura fulminans

And Microvascular thrombosis

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4
Q

Factor V Leiden pathophysiology ?

A

Resistant to degradation by protein C

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5
Q

Acquired disorders of thrombosis?

A
Catheter related
DIC
Plolycythemia (due to CHD)
Hypernatremia
Malignancy
SLE and APS
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6
Q

Clues for red cell aplasia?

A

Low retics
Absent red cell precursors
Normal bilirubin and negative Coombs

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7
Q

DBA caused by ?

Abnormal features?

A

Mutation in Ribosomal protein genes
80% sporadic
Short stature and abnormal thumbs

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