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PANCE > Hematology > Flashcards

Hematology Flashcards

1
Q

sickle cell anemia - labs

A

sickled cells on peripheral smear

Hgb S on hemoglobin electrophoresis

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2
Q

Thalassemia - labs

A

microcytic anemia with normal/ increased serum Fe or no response to Fe tx

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3
Q

G6PD Deficiency - labs

A

Episodic hemolytic anemia - sulfa drugs, fava beans, infections

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4
Q

Hereditary Spherocytosis - labs

A

microspherocytes, coombs negative, + osmotoic fragility test

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5
Q

Autoimmune hemolytic anemia - labs

A

microspherocytes, Coombs +

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6
Q

TTP - labs

A

normal coags

Pentad: thromobyctopenia, hemolytic anemia, kidney damage, neurolgic symptoms, fever

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7
Q

HUS - labs

A

normal coags
Triad: thrombocytopenia, hemolytic anemia & kidney disease
MC in children, kidney involvement

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8
Q

DIC - labs

A

abnormal coags (prolonged PT & PTT)

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9
Q

paroxysmal nocturnal hemoglobinuria - labs

A

dark urine, worse in the morning

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10
Q

Von Willebrand Disease

A

ineffective platelet adhesion
petechiae
decreased vWF levels, prolonged PTT (worse with aspirin)
decreased ristocetin activity test - gold standard

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11
Q

Hodgkin Disease (lymphoma)

A 
bimodal - 20yo and >50yo
reed sternberg cells 
B cell proliferation 
associated w/ EBV 
painless lymphadenopathy 
highly curable
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12
Q

Non Hodgkin Lymphoma

A

MC > 50 yo
Peripheral lymph nodes MC - local painless lymphadenopathy
Burkitt lympohma
unpredictable course

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13
Q

Multiple Myeloma (plasmacytoma)

A 
proliferation of single clone of plasma cells 
elderly >65, african american men MC 
bones break - hypercalcemia 
urine protein - bence-jones proteins 
CBC - rouleaux fomration 
Skull - punched out lytic lesions 
bone marrow - plasmocytosis 
Autologous stem cell transplant - definitive tx
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14
Q

ALL

A

MC childhood malignancy (3-7yo)
hepatosplenomegaly, fever, CNS symptoms
Bone marrow hypercellular with >20% blasts
PO chemo, combination

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15
Q

CLL(b cell)

A

B cell clonal malignancy
MC >50y caucasian males
peripheral smear - well differentiated lymphocytes with scattered smudge cells

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16
Q

AML

A 
MC acute form of leukemia in adults 
pancytopenia
leukostasis 
gingival infiltration 
bone marrow - auer rods  & >20% blasts
tumor lysis syndrome
17
Q

CML

A

blastic crisis, splenomegaly
+philadelphia chromosome
increased WBC counts
PO chemo + imatinib

PANCE (3 decks)

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