Hematology Flashcards
ABO typing required …
Rh typing required …
FFP, Cryo
Platelets
Blood typing is …
And screening is …
Determines ABO and Rh of the patient and screens common AB’s using indirect Coombs test
Screening is mixing patient’s serum with RBC of known Ag combination
Major cross matching is …
Donor PRBC mixed with recipient serum.
It determines whether recipient has preformed Ab in serum against the donor cell.
This reduces immediate hemolytic transfusion rxn, but dose not reduce delayed transfusion rxn.
Minor cross matching is …
Recipient RBC added to donor serum to identify donor serum Abs
Blood groups -> RBC Ag -> plasma Ab
Group RBC Ag Plasma Ab
A A B
B B A
AB A/B None -> universal recipient
O None AB -> universal donor
There is one type of AB blood patient that cannot receive O plasma?
The (-) AB patient cannot receive O (-) plasma
T/F:
A+ patient who received 10U of O- RBCs can still safely receive both A- and B- RBCs?
True
One unit of platelets increases count by …
5000 - 10,000 cells/mm
Contraindications to FFP?
Volume resuscitation
Hemophilia
Cryoprecipitate is rich in …
Factor 8
vWB factor
Fibrinogen
Cryo and factor 8 used to replenish factor 8 in hemophilia
T/F
You can replenish vWBF by giving recombinant Factor 8?
False
Acute reversal of warfarin by giving …
Plasma prothrombin concentrate
The most common cause of bleeding disorder after massive transfusion is …
Dilutional Thrombocytopenia
Hypocalcemia develops after massive transfusion due too …
Citrate toxicity (citrate chelates Ca)
The risk of citrate toxicity after massive transfusion increased in …
Neonates FFP or platelets transfusion Hyperventilation Liver disease Hypothermia
The specific indicator test for acute hemolytic transfusion rxn is …
Presence of + direct antiglobulin
Serum haptoglobin levels …. in acute hemolytic transfusion rxn
Decreased
The most common infection transmitted by blood transfusion is …
CMV
CMV > HepB > HepC > HIV
Bactermia is more common with … transfusion
Platelets
Type of blood transfusion and cause due to transfusion of donor …
Urticaria
Febrile
TRALI
GVHD
Transfusion rxn Donor
Urticaria -> plasma proteins
Febrile -> leukocyte Ag
TRALI -> leukocyte Ab
GVHD -> lymphocytes
The most common cause of transfusion related mortality is
TRALI
Caused by donor leukocyte Ab
CXR -> b/l diffuse infiltration
The only transfusion rxn associated with leucopenia is …
TRALI
Delayed hemolytic transfusion rxn occurs …. after transfusion and commonly due to … and characterized by …
Day to 21 days
Ab to Rh and other minor Ag
Decrease Hct, retics, and increased indirect bili
Leukocyte depleted blood reduces transmission of
Febrile transfusion rxn
CMV, EBV, and HTLV1 viruses
Leukocyte irradiated blood reduces … risk
GVHD
Transfuse washed cell done to remove …
Anti-IgA Ab
In IgA deficient patients which have anti IgA Ab results in anaphylaxis rxn
vWBD type …. responds to DDAVP (give electively prior surgery) but type … do not, and give … instead
Type 1 and 2A
Type 2B and type 3 respond to Cryo instead
However any VWB disease patient with active bleeding should get Cryo
