Hematology

Question 1

Physiologic Anemia of infancy for term and preterm infants

Answer 1

1. Term: 8-12 weeks of age, Hgb: 11g/dL

2. Preterm: 3-6 weeks of age, Hgb: 7-9g/dL

Question 2

Autosomal recessive disorder characterized by aplastic anemia with microcephaly, microphthalmia, hearing loss

Answer 2

Fanconi’s Anemia

Question 3

Most common anomaly of fanconi’s anemia

Answer 3

Hyperpigmentation

Question 4

Hallmark of Aplastic Anemia

Answer 4

Peripheral pancytopenia with hypoplastic or aplastic bone marrow

Question 5

Most common hematologic disease of infancy and childhood

Answer 5

Iron deficiency Anemia (microcytic hypochromic RBCs)

Question 6

Most common nutritional disorder

Answer 6

Iron deficiency anemia

Question 7

Most important clinical sign of IDA

Answer 7

Pallor

Question 8

Most common inherited abnormality of the RBC membrane

Answer 8

Hereditary Spherocytosis

Question 9

“crew cut” or “hair on end” appearance on skull radiographs

Answer 9

Sickle cell anemia

Question 10

Most common cause of thrombocytopenic purpura in childhood

Answer 10

Idiopathic Thrombocytopenic purpura in childhood

Question 11

5 cardinal symptoms of thrombotic thrombocytopenic purpura (TTP)

Answer 11

(FAT RN)

1. Fever
2. Anemia (microangiopathic, hemolytic type)
3. Thrombocytopenia
4. Renal dysfunction
5. Nervous system changes

Question 12

Bleeding disorder due to an acquired deficiency of ADAMTS-13

Answer 12

Thrombotic thrombocytopenic purpura

Question 13

Hallmark of hemophilic bleeding

Answer 13

Easy bruising, intramuscular hematomas, hemarthroses

Question 14

Most common inherited bleeding disorder?

Answer 14

von Willebrand Disease