Hematology Flashcards

1
Q

Plasma

A

fluid portion of blood, contains protein, globulin, fibrinogen, electrolytes,waste products and nutrients

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2
Q

Cellular components

A

Leukocyte
Erythrocytes
Platelets

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3
Q

Hematopoesis

A

Located in bone marrow,reproduction of cells

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4
Q

Under normal conditions the adult bone marrow produces the following daily:

A

RBC- lives 120 days
Neutrophils WBC- 13-20days
Platelets-10 days

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5
Q

Blood volume

A

7-10% normal body weight (5-6liters)

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6
Q

3 nutrients that help blood cells develope

A

Iron, protein, folic acid

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7
Q

Bone marrow

A

Site of hematopoiesis or blood cell formation

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8
Q

In diseases causing bone marrow destruction fibrosis scaring, liver and spleen can also

A

Resume production of blood cells

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9
Q

Marrow is highly

A

Vascular, within it are primitive cells called stem cells

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10
Q

Stem cells

A

Ability to replicate ensuring continuous supply trough out life. Differentiate into myeloid or lymphoid(B&T cells)

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11
Q

Myeloid differentiate into 3 broad cells

A

RBC, WBC, PLT

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12
Q

Defect in myeloid causes

A

WBC, RBC, plt production

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13
Q

Common name for circulatory vessels or ducts in which fluid bathes tissue cells absorbing digesting fat, removing and destroying toxic substance, resist spread of disease control edema

A

Lymphatic system

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14
Q

Fluid going through lymphatic system

A

Lymph

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15
Q

When infected or swollen it can be palpated if located near surface

A

Lymph nodes

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16
Q

Located in the ULQ, stores RBC and push them into circulation when needed

A

Spleen

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17
Q

Disorders of hemopoiesis

A

Problems of blood forming tissue, including blood cells, bone marrow, spleen and lymph system

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18
Q

RBC count

A
  1. 2-6.2 million in men

4. 2-5.4 million in women

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19
Q

Erythrocytes index

Aid in describing anemias

A

MCV- (RBC size) increase w/ pernicious anemia and folic acid

MCHC-(hemoglobin saturation) decrease in iron deficiency anemia, thalassemia and hypochromic anemia

MCH-(RBC weight) increase macrocyclic anemia, decrease hypochromic anemia

Notify md if out of range

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20
Q

Hgb,Hct levels

A

Hgb- male and female 12-18
Hct-male 40-50%, 37-47%

Hct -decreased in blood loss,anemias,leukemias, Hodgkin disease

Hgb-decreased in anemias, cancer, Hodgkin

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21
Q

Nonnucleated immature RBC, indicator bone marrow activity, represent the # or RBC not sufficient to carry o2

A

Reticulocyte

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22
Q

Measure rate of RBC settle out of uncloted blood
Decrease levels of sickle cell anemia, chf
Increase level of Hodgkin, rheumatoid arthritis

A

Sedimentation rate

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23
Q

Serum iron (IBC)

A

Helpful to classify anemias, differentiating acute from chronic disorders.
Increase= RBC destruction
Decrease=iron deficiency anemia

24
Q

Total iron binding capacity (TIBC)

A

Measures amount transferin can combine with
Transferin- plasma protein responsible for iron transportation to bone marrow for purpose of Hgb synthesis

Decreased=sickle cell anemia, hemolytic anemia
Increase=acute disorder

25
Serum bilirubin
Formed from break down of hgb carried in plasma to liver
26
Serum bilirubin | Conjugated
Direct reacting( soluble) increased= obstructive jaundice, liver cancer,wilsons disease,accumulation of copper in brain, liver, kidney,cornea. Something wrong with liver break down RBC
27
Serum bilirubin | Unconjucated
Indirect reacting(protein bound) increased= sickle cell anemia,transfusion reaction,hemolytic anemia, pernicious anemia Protein with blood break down RBC
28
Used to diagnose pernicious anemia.
Schilling test
29
Schilling test procedure
``` 24 hour urine collection Oral radioactive b12 administered Non radioactive 2 hr later No b12 3 days before test Laxative 24 h before test NPO 8-12 hours before ```
30
VIT. B12 essential for
RBC maturation
31
VIT. B12 is important for
Normal hemotopoiesis
32
The extrinsic factor of VIT. B12 is obtained from ____ and is _____ in the small intestines when intrinsic is present
Food | Absorbed
33
VIT. B12 intrinsic factor is produced by
Gastric mucosa
34
When intrinsic factor is missing
Pernicious anemia develops
35
Decreased VIT. B12 level
Pernicious anemia, Mel absorption syndrome
36
Increased VIT. B12 level
Acute/ chronic myelscytic leukemia, hepatitis
37
Serum folate level ( folic acid B9)
Needed for normal RBC and WBC formation useful for classifying anemias
38
Decreased level of folic acid
VIT. B6 anemia, folic acid anemia
39
Elevated folic acid levels
Pernicious anemia
40
Foods high in iron
* Beef liver * Blackstrap molasses * Chicken liver * Cooked oatmeal * Cooked prunes * Cooked shrimp * Dried apricots * Egg yolks * Kidney beans * Lean beef * Lima beans * Whole grains * Prune juice * Raisins * Spinach and green leafy vegetables * Turkey
41
Foods high in folic acid
``` Asparagus • Beef • Fish • Cabbage • Brussels sprouts • Broccoli • Legumes (kidney beans, etc.) • Liver • Eggs • Whole grains ```
42
Ng tube inserted- histamine injected to stimulate gastric secretions, gastric contents aspirated and analyzed
Gastric analysis
43
Achlorhydria ( absence of hc1)
Pernicious anemia
44
Sickledex test
Abnormal hgb causes RBC to form crescents or sickle shape. With adequate hgb and RBC maintain normal shape Sickling of cells in hypoxia suggest sickle cell trait or anemia
45
WBC count
4,500-11,000 Determine # of leukocyte Aid in diagnosis of infection and blood disorders such as leukemia
46
Determine type of infection, take before given antibiotics
Blood culture and sensitivity
47
WBC differential | Granular
Produced in red bone marrow Neutrophils- go directly to infection Eosinophils- got to pericites and pinworms Basophils- increase allergic reaction, release histamine
48
WBC differential | Agranular
Produced in lymphatic tissue of spleen, lymph nodes, thymus, and red bone marrow Lymphocytes Monocytes
49
Two types of lymphocytes
T cells | B cell
50
Decreased neutrophils
Leukemia | Iron deficiency anemias
51
Decreased monocytes
Lymphocytic leukemia | Aplastic anemia
52
Decreased lymphocytes
Cancer Leukemia Aplastic anemia
53
Increased neutrophils
Acute infection | Hodgkin disease
54
Increased basophils and monocytes
Leukemia
55
Increased lymphocytes
Lymphatic leukemia Chronic infection, Hodgkin disease