Hematology

Question 1

The diffrenced between CML and a leukmoid reaction are

Answer 1

Leukmoid: INCREASED LAP, INCREASED toxic granulation, Dohle Bodies, and Ph chromosome negative

CML: DECREASED LAP, DECREASED toxic granulation, NO Dohle bodies, Ph chromosome positive

Question 2

HCT NV

Answer 2

37-53%

Question 3

RDW NV

Answer 3

11.5-14.5 %

Question 4

Hemolysis and hemolytic anemia would cause Hgb A1c levels to

Answer 4

Decrease

Question 5

MCH equation

Answer 5

HGB/RBC x 10

Question 6

In POSThepatic jaundice (i.e. obstructive jaundice), describe the bilirubin results

Answer 6

Serum unconjugated: Normal
Serum conjugated: INCREASED
Urine Bilirubin: INCREASED
Urine Urobiliogen: DECREASED
Marked increased in GGT, AST, ALT

Question 7

MCHC NV

Answer 7

32-36 %

Question 8

In Hepatic jaundice (i.e. cirrosis, viral hepatitis), describe the bilirubin results

Answer 8

Serum Unconjugated: INCREASED
Serum Conjugated: INCREASED
Urine Bilirubin: 0 or INCREASED
Urine Uronbilinogen: INCREASED

Question 9

Nephrotic syndrom results from damage to the kidney. What will you find increased in the urine?

Answer 9

Albumin

Question 10

WBC NV

Answer 10

4.8-10.8 x10^9

Question 11

PLT NV

Answer 11

150-450 x10^9

Question 12

What does creatinine clearance help estimate?

Answer 12

The glomular filtration rate (the rate of blood flow through the kidneys)

Question 13

MCV NV

Answer 13

800-100 fL

Question 14

Where are Heinze bodies found and what are they composed of?

Answer 14

Inner RBC membrane

Denatured hemoglobin

Question 15

MCHC equation

Answer 15

HGB/HCT X 100

Question 16

MCH NV

Answer 16

27-31 pg

Question 17

HGB NV

Answer 17

M: 14-18
F: 12-16 g/dL

Question 18

Characteristics of G6PD deficiency

Answer 18

Causes hemolysic crisis
Jaundice (neonatal and adult)
Avoid Triggers
Malaria protection
HEINZ BODIES

Question 19

RBC NV

Answer 19

4.2-6.1 x10^9

Question 20

Heinz bodys can be seen in

Answer 20

G6PD deficiency
Alpha thalassemia
drug induced hemolytic anemia
chronic liver disease

SUPRAVITAL STAIN

Question 21

Corrected RBC formula

Answer 21

(uncorrected WBC x100)/(nRBCS/100) + 100

Question 22

MCV equation

Answer 22

HCT/RBCs x 10

Question 23

Acute myelogenous leukemia: to many _____

Chronic myelogenous leukemia: to many _____

Answer 23

AML: blasts
CML: mature cells (mostly affects adults)

Question 24

Normal Values
WBC
RBC
HGB
HCT
MCV
MCH
MCHC
RDW
PLT

Answer 24

WBC       4.8-10.8   x 10^9 L
RBC        4.2-6.1     x10^6 uL
HGB M   14-18        g/dL
HGB F    12-16        g/dL
HCT        37-52       %
MCV       80-100     fL
MCH       27-31        pg
MCHC    32-36       %
RDW       11.5-14.5   %
PLT         150-450    x10^9

Question 25

In Alpha Thalassemia (also known by its defective hemoglobin), these two unstable hemoglobins are present. Describe abnormal blood smear findings

Answer 25

``` Hemoglobin Barts (tetrameric gamma chains) Hemoglobin C (tetrameric beta chains) ``` Microcytic anemia, target cells, HEINZ bodies

Question 26

How is indirect (uncongugated) bilirubin converted into direct (congugated) bilirubin?

Answer 26

Uncongugated bilirubin is conjugated with two molecules of glucaronic acid (enzyme glucuronyl transferase)

Question 27

Napathalene poisoning is evident by seing this in a blood smear (suprvital)

Answer 27

Heinze bodies

Question 28

In PREhepatic jaundice (i.e. hemolytic anemia), describe the bilirubin results.

Answer 28

Serum Unconjugated: INCREASED Serum Conjugated: Normal Urine bilirubin: 0 Urine Urobilinogen: INCREASED

Question 29

Multiple Myeloma smear findings

Answer 29

Rouleux NRBCs Teardrop Cells

Question 30

The major iron storage compound is

Answer 30

ferritin

Question 31

Iron Labs in Iron Deficiency

Answer 31

DECREASED serum ferritin DECREASED serum Fe INCREASED TIBC DECREASED sautration

Question 32

Iron Labs in Chronic Disease/Inflammation

Answer 32

N-INCREASED serum ferritin DECREASED serum Fe DECREASED TIBC

Question 33

Iron Labs in Lead Poisoning

Answer 33

Basophilic Stippling Increased Pb Increased FEP

Question 34

Which hemoglobins migrates with A2

Answer 34

C E O arab C harlem A2 CE Of Clubes

Question 35

Which hemogbolins migrate with S

Answer 35

D G Lepore Sad Dogs Get Loved

Question 36

A patients lymphocytes demonstrate cytoplasmic projects and a POSITIVE TARTRATE-RESISTANT acid phosphatase stain. What is the most likely diagnosis?

Answer 36

Hair Cell leukemia

Question 37

Bernard Soulier syndrome is characterized by

Answer 37

Increased bleeding time | Giant platelets

Question 38

Vitamin K dependent factors

Answer 38

II VII IX X

Question 39

von Willebrands # PLTs PLT morphology Assay"

Answer 39

PLTs: normal PLT morpholgy: normal Assay: abnormal adhesion, ristocetin decreased, vWF is absent

Question 40

What is commonly associated with CMML

Answer 40

lysozymuria

Question 41

In CML, blood histamine levels reflect

Answer 41

the amount of basophils present

Question 42

The Phillidelphia chromosome is most closely releated to

Answer 42

Chronic myelogenous leukemia

Question 43

All stages of neutrophils are likely to be seen in the peripheral blood in CML/AML

Answer 43

CML

Question 44

1/3 of CML cases progress to

Answer 44

ALL | Acute lymphocytic leukemia

Question 45

Chronic lymphocytic leukemia is defined as

Answer 45

accumulation of monoclonal B cells with a block in maturation