Hematology Flashcards
Hypersegmented neutrophils
B12 and folate deficiency
Rouleaux formation
Multiple myeloma ++
Infection/inflammation
Howell-jolly bodies
Splenectomized pts
Target cells
Sickle cell dz, thalassemia
Basophilic stippling/ringed sideroblasts
Lead poisoning
Sideroblastic anemia
Low serum iron
Low ferritin
High TIBC
Iron deficiency anemia
Low serum iron
High ferritin
Low TIBC
Anemia of chronic disease
Microcytic anemia
Normal serum iron
Thalassemia
Inciting factors for G6PD anemia
Infection
Sulfa
Fava beans
Antimalarials
TTP/HUS
TCP
Nl PT/PTT
HUS - kidney dysfunction
TTP/HUS rx
Plasmapheresis
May hold off in peds with HUS
Labs in DIC
Elevated PT/PTT
TCP
Schistocytes
Decreased fibrinogen
ITP labs
Isolated TCP
Hemophilia A rx
Factor VIII infusion
+/- desmopressin
Hemophilia B rx
Factor IX infusion
Von Willebrand disease rx
Desmopressin +/- factor VIII
Hodgkin lymphoma presentation
Upper body painless LAD - pain with etoh
B symptoms
Hodgkin lymphoma dx
Reed-Sternberg cells
Non-Hodgkin lymphoma presentation
Painless peripheral LAD
Extra-nodal sites - GI, skin, CNS
Multiple myeloma dx
Monoclonal protein spike
Urine bence-jones proteins
Rouleaux formation
Punched out bone lesions
ALL
Peds
Bone marrow hypercellular with >20% blasts
CLL
MC leukemia in adults
Smudge cells
Asymptomatic
AML
Auer rods
> 20% blasts
Risk of tumor lysis syndrome
CML
Philadelphia chromosome
High WBC
Auer rod
AML
Philadelphia chromosome
CML
Reed-Sternberg cells
Hodgkin lymphoma
Polycythemia Vera rx
Phlebotomy + hydroxyurea
