Hematology Flashcards
Primary regulator of erythropoiesis
Kidney
Maturation stage of RBC
Pronormoblast (rubriblast)
Basophilic normoblast (prorubricyte)
Polychromatic normoblast (rubricyte)
Orthochromic normoblast (metarubricyte)
Polychromatic erythrocyte (reticulocyte)
Mature erythrocyte
1st stage of hgb appearance
Basophilic normoblast (rubriblast)
Last stage of capable of cell division and start of hgb production
Polychromatic normoblast (rubricyte)
Last nucleated stage, pyknotic nucleus
Polychromatic normoblast (metarubricyte)
No more nucleus, reticulum of RNA
Polychromatic erythrocyte (reticulocyte)
Rbc lifespan
120 days
No. of erythrocyte produced from each pronormoblast
8-32 rbc ave. 16
It determines the survival /lifespan or rbc
Chromium
Nucleus lag
Cause:
Charac:
Ex.:
Megaloblastic
Vit. B12 or folic acid deficiency
Oval macrocyte
Pernicious anemia
Cytoplasm lags
Cause:
Charac:
IDA
Iron deficiency
Microcytic, hypochromic rbcs
General cell maturation charac for leukocytes
Immature cells
-large
-nucleoli present
-dark blue cytoplasm, rich in RNA
-high N:C ratio
Mature cells
-smaller
-nucleoli absent
-light blue cytoplasm, less RNA
- low N:C ratio
Maturation stage of Granulocyte
Myelobast
Promyelocyte
Myelocyte
Metamyelocyte (juvenile)
Band
Mature Granulocyte
Earliest recognition stage in the series
Myelobast
Appearance of primary/nonspecific/azurophilic granules
Promyelocyte
Appearance of secondary granules/specif gran. & last stage of cell division
Cells:
Myelocyte
Neutrophil- rose pink granules
Eosinophil - orange red granules
Basophil- blue-black purple granules
Youngest cell predominant in BM not capable of mitosis
Cell shape:
Metamyelocyte
Indented or kidney shaped
Youngest stage to normally appear PB
Cell shape:
Band
Curved or elongated nucleus (sausage shape)
Cells under mature granulocyte
Seg. Neutrophil - phagocytosis
Eosinophil - 1° function : suppression of immune response, t. spiralis
Basophil- effector cell of type 1 hypersensitivity, water soluble
No. of lobes in granulocytes cell
Neutrophil- 2-5 lobes
Eosinophil- 2 lobes
Basophil- 2 or 3-4 lobes
Granulocytes capable of mitosis
Myelobast (15hrs)
Promyelocyte (24 hrs)
Myelocyte (4.3 days)
Cell division for Granulopoeisis
4-5 division ( omplete)
Maturation time for mature granulocyte
Neutrophil - 7-10 days
Eosinophil - 2.5 days
Basophil - 12 hrs
Mature granulocytes time in circulation
Neutrophil - 7-10 hrs
Eosinophil - few hrs
Basophil - 8.5 hrs
