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LEMAR NOTES (RMT, 2023) > Hematology > Flashcards

Hematology Flashcards

1
Q

Primary regulator of erythropoiesis

A

Kidney

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2
Q

Maturation stage of RBC

A

Pronormoblast (rubriblast)
Basophilic normoblast (prorubricyte)
Polychromatic normoblast (rubricyte)
Orthochromic normoblast (metarubricyte)
Polychromatic erythrocyte (reticulocyte)
Mature erythrocyte

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3
Q

1st stage of hgb appearance

A

Basophilic normoblast (rubriblast)

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4
Q

Last stage of capable of cell division and start of hgb production

A

Polychromatic normoblast (rubricyte)

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5
Q

Last nucleated stage, pyknotic nucleus

A

Polychromatic normoblast (metarubricyte)

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6
Q

No more nucleus, reticulum of RNA

A

Polychromatic erythrocyte (reticulocyte)

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7
Q

Rbc lifespan

A

120 days

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8
Q

No. of erythrocyte produced from each pronormoblast

A

8-32 rbc ave. 16

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9
Q

It determines the survival /lifespan or rbc

A

Chromium

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10
Q

Nucleus lag

Cause:
Charac:
Ex.:

A

Megaloblastic

Vit. B12 or folic acid deficiency
Oval macrocyte
Pernicious anemia

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11
Q

Cytoplasm lags

Cause:
Charac:

A

IDA

Iron deficiency
Microcytic, hypochromic rbcs

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12
Q

General cell maturation charac for leukocytes

A

Immature cells
-large
-nucleoli present
-dark blue cytoplasm, rich in RNA
-high N:C ratio

Mature cells
-smaller
-nucleoli absent
-light blue cytoplasm, less RNA
- low N:C ratio

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13
Q

Maturation stage of Granulocyte

A

Myelobast
Promyelocyte
Myelocyte
Metamyelocyte (juvenile)
Band
Mature Granulocyte

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14
Q

Earliest recognition stage in the series

A

Myelobast

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15
Q

Appearance of primary/nonspecific/azurophilic granules

A

Promyelocyte

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16
Q

Appearance of secondary granules/specif gran. & last stage of cell division

Cells:

A

Myelocyte

Neutrophil- rose pink granules
Eosinophil - orange red granules
Basophil- blue-black purple granules

17
Q

Youngest cell predominant in BM not capable of mitosis

Cell shape:

A

Metamyelocyte

Indented or kidney shaped

18
Q

Youngest stage to normally appear PB

Cell shape:

A

Band

Curved or elongated nucleus (sausage shape)

19
Q

Cells under mature granulocyte

A

Seg. Neutrophil - phagocytosis
Eosinophil - 1° function : suppression of immune response, t. spiralis
Basophil- effector cell of type 1 hypersensitivity, water soluble

20
Q

No. of lobes in granulocytes cell

A

Neutrophil- 2-5 lobes
Eosinophil- 2 lobes
Basophil- 2 or 3-4 lobes

21
Q

Granulocytes capable of mitosis

A

Myelobast (15hrs)
Promyelocyte (24 hrs)
Myelocyte (4.3 days)

22
Q

Cell division for Granulopoeisis

A

4-5 division ( omplete)

23
Q

Maturation time for mature granulocyte

A

Neutrophil - 7-10 days
Eosinophil - 2.5 days
Basophil - 12 hrs

24
Q

Mature granulocytes time in circulation

A

Neutrophil - 7-10 hrs
Eosinophil - few hrs
Basophil - 8.5 hrs

LEMAR NOTES (RMT, 2023) (1 decks)

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