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SDC - INVESTIGATIONS > HÉMATOLOGIE: EXAMEN 1 > Flashcards

HÉMATOLOGIE: EXAMEN 1 Flashcards

1
Q

Méthodes d’investigation: cellules sanguines (GR, GB, PLAQ)

A

FSC
Frottis
Détermination des antigènes

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2
Q

Méthodes d’investigation: protéines plasmatiques

  • Coagulation
  • Transport
  • Ig
  • Complément
A 
Électrophorèse
Immunofixation
VS
Dosage: fibrinogène, Ig
Tests de coagulation
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3
Q

Méthodes d’investigation: Hb

A

Dosage
Électrophorèse
P50
CarboxyHb

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4
Q

Méthodes d’investigation: érythrocytes

A

FSC
Isotopes (durée de vie)
Produits de dégradation (LDH, bili, haptoglobine)

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5
Q

Méthodes d’investigation: MO-hématopoïèse

A

Indirecte (FSC):

  • Réticulocytose (GR)
  • Stabs/myélocytes/métamyélocytes (GB)
  • VPM: volume plaquettaire moyen (PLAQ)

Directe:

  • Aspiration: myélogramme
  • Biopsie
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6
Q

Insuffisance médullaire

A

FSC: rétic, stbas
Aspiration (richesse/cellularité)
Biospie (a/hypo/hyper/dysplasie, adipocytes, néo, fibrose)

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7
Q

Splénomégalie

A

E/P
Écho abdo +/- doppler
Scintigraphie hépato-splénique
TDM

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8
Q

Investigation initiale : anémie

A

FSC
Frottis
Réticulocytose

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9
Q

Anémie normocytaire-normochrome non-régénérative

A
  • Bilan martial: fer sérique, ferritine, % sat transferrin, capacité fixation
  • Créatinine, TSH
  • Aspiration-biospie MO
  • Caryotype (Ph1)
  • PCR: bcr-Abl, JAK2-CARL-MPL
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10
Q

Anémie normocytaire-normochrome régénérative

A
  • R/O hémorragie aiguë
  • Tests de Coombs
  • Bilan d’hémolyse: LDH, Bilirubine, Haptoglobine
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11
Q

Anémie microcytaire-hypochrome non-régérative

A
  • Bilan martial: fer sérique, ferritine, % saturation transferrine, capacité fixation
  • PCR, VS, tests inflammation
  • Électrophorèse Hb
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12
Q

Anémie macrocytaire non-régénérative

A
  • Bilan hépatique (LDH, bili, AST, ALT, GGT, Palc)
  • Dosage B12
  • Dosage acide folique (demande hémato)
    (Aspi-biopsie: pas faire en clinique)
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13
Q

Érythrocytose

A
  • JAK2
  • CarboxyHb
  • P50
  • SaO2
  • Imagerie rein/abdo
  • Dosage EPO
  • Aspi-biopsie MO
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14
Q

Mononucléose infectieuse

A

FSC
Bilan hépatique (LDH, bili, AST, ALT, GGT, Palc)
Monotest

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15
Q

Cancer hématologique

A
  • FSC
  • Frottis
  • Aspi-biospsie MO
  • Biospie ganglion
  • Cytométrie de flux
  • Caryotype/FISH
  • PCR
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16
Q

LMA

A
  • FSC
  • Frottis
  • Aspi-biopsie MO
  • PCR: PML-RARA
17
Q

SMD

A
  • FSC, frottis
  • Dosage B12, acide folique
  • Aspi-biospie MO
  • Caryotype
18
Q

LMC

A
  • FSC, frottis
  • Aspi-biopsie MO
  • Caryotype: Ph1
  • PCR: bcr-Abl
  • Acide urique
19
Q

Myélofibrose essentielle

A
  • FSC, frottis
  • Aspi-biospie MO
  • PCR: JAK2, CARL, MPL
20
Q

Thrombocytopénie essentielle

A
  • FSC
  • Aspi-biospie MO
  • PCR: JAK2, CARL, MPL
21
Q

Polyglobulie de Vaquez

A
  • FSC
  • Aspi-biospie MO
  • PCR: JAK2
  • Dosage EPO

SDC - INVESTIGATIONS (9 decks)

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