Hematological Malignancies Flashcards
how is Leukaemia Classified?
What cells are indicative of leukaemia classifications
what characteristics are used to classify leukaemia
Now based on WHO classification system of classification
o Morphology, immunophenotype, genetic
Why do we bother classifying the leukaemias?
Different prognosis
o Different treatment regimens
What is Acute Myeloid Leukaemia (AML)
Abnormal proliferation of myeloid blasts in the bone
marrow (maturational arrest)
* Highly heterogeneous with a variable prognosis
how is AML Classified?
o ≥ 20% blasts in the bone marrow or peripheral blood
how many main subgroups of AML
6
explain the AML subgroups – Recurrent genetic abnormalities
t(15;17) PML-RARA
* PML – promyelotic leukaemia gene
* RARα is a retinoic acid receptor
* PML-RARα fusion protein acts as a
transcriptional repressor, interfering with gene
expression and arresting maturation beyond the
promyelocyte stage
