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HEMA > HEMATOLOGIC NEOPLASMS > Flashcards

HEMATOLOGIC NEOPLASMS Flashcards

1
Q

Comprises 5% AML
[2]

A

FAB M0 Actue Myeloid Leukemia, Minimally Differentiated

FAB M3 Acute Promyelocytic Leukemia

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2
Q

FAB M0 [AML, MINIMALLY DIFFERENTIATED]

[+/-] AUER RODS

A

NEGATIVE

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3
Q

NEGATIVE MPO, SBB

A

FAB M0

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4
Q

IMMUNIPHENOTYPING: CD13, CD33, CD34,117

A

M0 AML, MIN. DIFFERENTIATED
M1 AML, W/O MATURATION
M2 AML, W/ MATURATION

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5
Q

NO CELLULAR MATURATION EVIDENCE

A

AML, MIN. DIFFERENTIATED M0

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6
Q

> 90% MYELOBLASTS
</> 10% LEUKOCYTES SHOW MATURATION TO THE PROMYELOCYTE STAGE

A

ACUTE MYELOID LEUKEMIA, W/O MATURATION

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7
Q

PRESENCE OF AUER RODS

PRESENCE OF AUER RODS [BUNDLES-FAGGOT CELLS]

A

FAB M1 AML, MIN. DIFFERENTIATED
FAB M2 AML, W/O MATURATION
FAB M4 ACUTE MONOMYELOCYTIC LEUKEMIA

FAB M3 AML, W/ MATURATION

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8
Q

POSITIVE FOR MPO, SBB, CAE

A

FAB M1 AML, W/O
FAB M2 AML, W/
FAB M3 PROMYELOCYTIC

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9
Q

PRESENCE OF CHLOROMA (green appearance of tissue using MPO)

A

FAB M1 W/O

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10
Q

ACCOUNTS FOR 50% of AML CASES

A

FAB M1/M2

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11
Q

90% MYELOBLASTS
10% MATURING NEUTRO LINEAGE
20% PRECURSORS W/ MONOCYTIC LINEAGE

A

FAB M2, W/

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12
Q

AML, W/ MATURATION [FAB M2]
genetic translocation:

A

t(8;21) (q22;q22.1)
RUNX1/ RUNX1T1

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13
Q

genetic translocation of Acute Promyelocytic Leukemia [FAB M3]

A

BALANCED TRANSLOCATION:
t(15;17)
PML gene - RaRa gene= PML-RaRa

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14
Q

+30% ABNORMAL PROMYELOCYTES

2 TYPES:
1.
associated w/ [diseases + results{

  1. /
    [nucleus appearance]
A

Hypergranular
DIC +
HLA -

Hypogranular/Microgranular
“butterly” coin-on-coin appearance

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15
Q

FAB M3 Treatment

A

all-trans-retinoic acid
arsenic trioxide (ATRA)

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16
Q

NAEGELI’S TYPE

A

FAB M4
ACUTE MYELOMONOCYTIC LEUKEMIA

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17
Q

FAB ___— FAB M4 variant w/ myeloblasts + monoblasts + _________

A

FAB M4Eo
Abnormal Eosinophils

18
Q

> 30% of AML Cases

A

FAB M4, ACUTE PROMYELOCYTIC LEUKEMIA

19
Q

> 30% of AML CASES

> 20% WHO / >30% FAB: MARROW MYELOBLASTS

> 20% to __%: MONOCYTIC REGION

_______

A

80%

FAB M4

20
Q

MONOCYTIC IMMUNOPHENOTYPING FOR FAB M4

A

CD4, CD 11b/c, CD 14/64, CD 36, CD 68, LYZOZYME

21
Q

POSITIVE FOR MPO, SBB, CAE + NSE

A

FAB M4

22
Q

FAB M5 CYTOGENETIC ABN:

A

t(8;16) p(11;13) + M5/M4

23
Q

COMPRISES 10% of AML CASES

A

FAB M5

24
Q

FAB M5 is divided into 2 TYPES dependent on the degree of maturity:

  1. BM%___[children/adult]
  2. BM%___[children/adult]
A
  1. FAB M5a
    Schilling’s Type
    AML w/o maturation
    AML poorly undifferentiated

> 80% children

2.
FAB M5b
AML w/ maturation
AML well-differentiated

<80% adults (middle-aged)

25
Q

WHAT FAB IS THIS:
CD4, CD11b, CD11c, CD14, CD 64

A

FAB M5

26
Q

POSITIVE FOR NSE

A

FAB M4 MYELOMONOCYTIC
FAB M5 MONOCYTIC

27
Q

ABN, COMPRISING CYTOGENETIC TRANSLOCATION OF chromosome 8 short-arm 11 to chromosome 16 short-arm 13

A

FAB M5

28
Q

DISEASE PRESENT IN ACUTE ERYTHROLEUKEMIA
____

FAB M__

A

Di Guglielmo’s Syndrome

FAB M6

29
Q

> 50% DYSPLASTIC NARROW NORMOBLASTS

FAB M__

A

FAB M6

30
Q

> 50% DYSPLASTIC NARROW NORMOBLASTS

FAB M__

[PURE/ ACUTE]

A

FAB M5

31
Q

> 80% ERYTHROID CELLS (RBC)
30% PROERYTHROBLASTS

FAB M__
[PURE/ ACUTE]

A

6
PURE

32
Q

Acute Erythroleukemia

[2 Morphological Abn]

A

Ringed sideroblasts
Howell-Jolly Bodies

33
Q

WHAT FAB IS THIS:
CD 13, CD 15, CD33, CD 117

A

ACUTE ERYTHROLEUKEMIA FAB M6

34
Q

POSITIVE FOR PAS

A

FAB M6 ACUTE ERYTHROLEUKEMIA
FAB M7 ACUTE MEGAKARYOBLASTIC LEUKEMIA

35
Q

FAB M6 IMMUNOPHENOTYPING
ERYTHROBLASTS:

A

CD 45, CD 71 [GLYCOPHORIN A]

36
Q

RAREST AML

A

ACUTE MEGAKARYOBLASTIC LEUKEMIA FAB M7

37
Q

HAS __% MEGAKARYOCYTIC ORIGIN

FAB M__

A

50
7

38
Q

FAB M7 ACUTE MEGAKARYOBLASTIC LEUKEMIA IMMUNOPHENOTYPING:

A

CD 41[gpIIb]
CD 42 [gbIb]
CD 61 [gpIIIa]
vWF

39
Q

CD MARKERS associated with
1. gpIIb :
2. gpIa :

A

CD 41
CD 61

40
Q

POSITIVE FOR Alpha Naphthyl acetate esterase

A

FAB M7 ACUTE MEGAKARYOBLASTIC LEUKEMIA

HEMA (4 decks)

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