Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

KN-PharmHematology > Hematologic Malignancy Drugs > Flashcards

Hematologic Malignancy Drugs Flashcards

1
Q

What does induction mean?

A

high dose combination chemo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What does consolidation mean?

A

repetition of induction therapy during remission

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What does maintenance mean?

A

long term, lower dose therapy during remission

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is hormesis?

A

adaptive response of cell to moderate, intermittent stress, that can result in cell proliferation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What does befuzizumab do?

A

anti-VEGF drug that prevents angiogenesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

anthracyclines, taxanes and cyclophosphamides

A

can stimulate T cells. Can increase antitumor immune response, and inhibit TREG cells.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What drugs are used to treat AML?

A

ARA-C (pyrimidine analogue antimetabolite), thioguanine (purine antimetab), and daunorubicin (free radical generator)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is gemtuzomab?

A

old unsuccessful drug. antibody against CD-33 which is almost exclusively found on myeloid blast cells. It delivers a cytotoxic chemo.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is acute promyelocytic leukemia? What drugs are useful to treat it?

A

fusion of PML and RARA.

Can be treated with ATRA, which disrupts the fusion. Often combined with anthracyclines and cytarabine.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is arsenic trioxide?

A

similar to ATRA. cardiovascular toxicity.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What drug is used to treat acute lymphoblastic leukemia with the philadelphia t(9;22) mutation?

A

imatinib. It is an oral BCR-ABL tyrosine kinase inhibitor. Few toxicities. Can be used indefinitely.
methotrexate also given.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What drugs would be used to treat inductively acute lymphoblastic leukemia?

A

prednisone (corticosteroid), vincristine, and anthracycline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What drugs would be used in consolidation therapy for acute lymphoblastic leukemia?

A

methotrexate and mercaptopurine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What drugs are used to treat acute phase myeloid leukemia?

A

classical chemos

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What drugs are used to treat chronic phase myeloid leukemia?

A

imatinib. It is not very useful for acute phase however.
Nilotinib
AND
Dasatinib (both are similar to imatinib but have alternate binding geometry to counteract resistances)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How is CLL treated?

A

Fludarabine (antimetabolite)
Cyclophosphamide (alkylating agent)
Rituximab (anti CD20 antibody, induces complement and ADCC)
Alemtuzumab (antiCD52, on lymphos, monos, and DCs)
Bendamustine (both antimetabolite and alkylate, causes DNA crosslinking, activates p53 apoptosis and mitotic catastrophe)

17
Q

How is hary cell leukemia treated?

A

purine analogs
AND
interferon - prolong phases of cell cycle and induce differentiation. Activate host killer T cells, macros and monos.

18
Q

How are hodgkin lymphomas treated?

A 
Usually doxarubicin (anthracycline)
Vincristine (mitotic spindle inhibitor)
cyclophosphamide (alkylating agent)
carbazene
corticosteroid
19
Q

How are non-hodgkin lymphomas treated?

A

COMP (cyclophosphamide, vincristine, methotrexate, and prednisone)
CD20 Rituximab also effective

20
Q

What is the most limiting adverse effect of hodgkin lymphoma chemo?

A

myelosuppression is most severe and limiting

21
Q

What are adverse effects of non-hodgkin lymphoma chemo?

A

treatment-induced secondary malignancies

22
Q

List the drugs that are monoclonal CD20 antibodies?

A

Rituximab
Tositumomab (radiation)
Ibritumomab (radiated)

23
Q

How is Burkitt Lymphoma treated?

A

usually intrathecally because CNS is hard to penetrate

24
Q

What is the significant toxicity of Arsenic trioxide?

A

acute promyelocytic leukiemia differentiation syndrome, AV block, cardiac arrythmias

25
Q

What is the significant toxicity of ATRA?

A

acute promyelocytic leukemia differentiation syndrome, leukocytosis

26
Q

What is the significant toxicity of Bleomycin?

A

idiosyncratic reaciton (fever), pulmonary fibrosis

27
Q

What is the significant toxicity of busulfan?

A

bone marrow suppression, secondary malignancies

28
Q

What is the significant toxicity of Chlorambucil?

A

bone marrow suppression, secondary malignancy, teteragen, infertility

KN-PharmHematology (2 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions