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hematologic malignancy > hematologic malignancy > Flashcards

hematologic malignancy Flashcards

1
Q

Cytogenetic markers: CD34

A

general immature cells (lymphoblast or myeloblast)

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2
Q

Cytogenetic markers: Tdt

A

immature lymphoblast

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3
Q

Cytogenetic markers: CD19

A

precursor B cell

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4
Q

Cytogenetic markers: CD22

A

precursor B cell

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5
Q

Cytogenetic markers: CD3

A

precursor T cell

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6
Q

Cytogenetic markers: CD7

A

precursor T cell

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7
Q

B-ALL with t(9;22) BCR-ABL1

A

Philadelphia Chromosome

More seen in adults than children, worst prognosis of B-ALL sub-types

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8
Q

B-ALL with translocation of 11q23

A

MLL (mixed lineage leukemia)

Neonates/young infants, poor prognosis

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9
Q

B-ALL with t(12;21) ETV6-RUNX1

A

Favorable prognosis associated with RUNX1

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10
Q

AML with t(8;21) RUNX1-RUNX1T1

A

diagnostic of AML
younger patients
Relatively Good prognosis

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11
Q

AML with inv(16) or t(16;16)(p13.1;q22) CBFB-MYH11

A 
diagnostic of AML
younger patients. 
"baso eos" cells
myelomonocytic leukemia. 
Relatively Good prognosis
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12
Q

AML with t(15;17) PML-RARA

A

Acute Promyelocytic leukemia (APL) cytogenetics are diagnostic

Important to recognize:

     - RARA blocks differentiation but can be overcome with all-trans retinoic acid treatment - leads to good prognosis.
- Associated with DIC
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13
Q

AML with t(1;22) RBM15-MKL1

A

Most common in infants with Down syndrome
Megakaryoblastic differentiation
Relatively Good prognosis

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14
Q

AML with 11q23 MLL

A

Monocytic differentiation

Poor prognosis

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15
Q

therapy-related AML - alkylating agents

A

2-8 years after treatment, prior MDS stage, complex karyotype with partial loss of chromosome 5 and/or 7

POOR PROGNOSIS

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16
Q

therapy-related AML - topoisomerase-II inhibitors

A

1-2 years after treatment, no MDS stage, rearrangement of MLL gene

POOR PROGNOSIS

17
Q

FLT3 ITD

A

AML NOS marker

Poor prognosis - trumps all other markers

18
Q

NPM1 mutation

A

AML NOS marker

good prognosis

19
Q

CEBPA mutation

A

AML NOS marker

good prognosis

hematologic malignancy (1 decks)

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