Hematologic Malignancies

Question 1

3-7 y/o child with lymphadenopathy, bone pain, bleeding, and fever. Bone marrow > 20% blasts

Answer 1

Acute lymphocytic leukemia (ALL)

Question 2

60-year-old male complains of fatigue, blood tests demonstrate severe anemia, SMUDGE CELLS on peripheral smear, mature lymphocytes

Answer 2

Chronic Lymphocytic Leukemia (CLL)

Question 3

A 54-year-old patient with anemia, nosebleeds, bruising, thrombocytopenia, neutropenia. Splenomegaly, gingival hyperplasia and bone pain myeloblasts in bone marrow > 20% and Auer Rods

Answer 3

Acute Myeloid Leukemia (AML)

Question 4

64 year old with strikingly increased WBC count, hyperuricemia. Genetic testing demonstrates translocation of chromosome 9 and 22

Answer 4

Chronic Myeloid Leukemia (CML)

Question 5

Fever, chills, and night sweats for 1 month. Painless enlarged posterior cervical and supraclavicular lymph nodes bilaterally. CXR - mediastinal adenopathy. Excisional biopsy of lymph node shows Reed-Sternberg cells

Answer 5

Hodgkin’s Lymphoma

Question 6

HIV Patient with GI symptoms and painless peripheral lymphadenopathy

Answer 6

Non-Hodgkin Lymphoma

Question 7

65-year-old with bone and back pain refractory to treatments. Serum protein electrophoresis monoclonal protein Spike (IgG or IgA). Urine protein electrophoresis Bence Jones Protein. Skull X-ray demonstrates lytic (punched out) bone lesions

Answer 7

Multiple myeloma