Hematologic Cancers Flashcards
1
Q
ALL.
Age group Pathophys Presentation Markers Smear Tx
A
-
2
Q
CLL
Age group Pathophys Presentation Markers Smear Tx
A
- > 50
- Slowly progressive malignancy of B lymphocytes that results in accumulation of small, incompetent B cells
- Asymptomatic. Fatigue, LAD, HSM.
- Lymphocyte count greater than 5000
- B-cell antigens: CD19/20/23, t cell antigen
- smudge cells, warm antibody AI hemolytic anemia
- BMT + all others
3
Q
HCL
Age group Pathophys Presentation Markers Smear Tx
A
- 50yo
- Accumulation of hairy cells and reticulin fibrosis in bone marrow
- Splenomegaly. Bleeding. Infxns. Thrombocytopenia and leukcytopenia.
- Stains TRAP+
- Hair. Fried egg.
- 2-CdA
4
Q
AML
Age group Pathophys Presentation Markers Smear Tx
A
- Adults (most common in)
- Immature myeloid cells in bone marrow and fuck up hematopoiesis
- Pancytopenia and associated sx’s
- MPO. Sudan black stain. KIT.
- Auer rods
- All trans retinoic acid
5
Q
CML
Age group Pathophys Presentation Markers Smear Tx
A
- 30-60
- 9,22: abl-bcr
- insidious onset. Low LAP.
- increase granulocytes and less than 5% blasts.
- imatinib: antibody to philly chrom.
