Hematologic

Question 1

Agranulocytosis

Answer 1

Can Cause Pretty Major Collapse of Granulocytes

Clozapine
Carbamazepine 
Propylthiouracil
Methimazole
Colchicine 
Gancyclovir

Question 2

Aplastic anemia

Answer 2

Can’t Make New Blood Cells Properly

Carbamazepine 
Methimazole
NSAIDs
Benzene
Chloramphenicol 
Polypylthiouracil

Question 3

Direct Coombs positive hemolytic anemia

Answer 3

Methyldopa

PCN

Question 4

Drug reaction with eosinophilia and systemic distress (DRESS)

Answer 4

Potentially fatal delayed hypersensitivity rxn, latency period of 2-8 weeks followed by fever, mobilliform skin rxn, and frequent multiorgan involvement
Tx: withdraw drug, corticosteroids

Allopurinol
Anticonvulsants
Abx
Sulfa drugs

Question 5

Gray baby syndrome

Answer 5

Chloramphenicol

Question 6

Hemolysis in G6PD deficiency

Answer 6

Hemolysis IS D PAIN

Isoniazid
Sulfonamides
Dapsone
Primaquine
Aspirin
Ibuprofen
Nitrofurantoin

Question 7

Megaloblastic anemia

Answer 7

YoU’Re having a mega blast with PMS

hydroxYURea
Phenytoin
Methotrexate
Sulfa drugs

Question 8

Thrombocytopenia

Answer 8

Heparin

Question 9

Thrombotic complications

Answer 9

Combined oral contraceptives
Hormone replacement therapy
SERMs (Tamoxifen, Raloxifene, Clomiphene)