Hema Drugs

Question 1

Heparin Antidote

Answer 1

Protamine Sulfate

Question 2

Warfarin Antidote

Answer 2

Vitamin K

Question 3

Dabigatran antidote

Answer 3

Idarucizumab

Question 4

Direct Factor Xa Inhibitor (e.g., Apixaban, edoxaban, rivaroxaban)

Answer 4

Andexanet Alfa

Question 5

Aspirin

Answer 5

Irreversible block in COX therefore causing dec TXA2

Question 6

Clopidogrel, ticagrelor, ticlopidine

Answer 6

MOA: Blocks P2Y12 receptor — dec ADP-induced expression if GpIIb/llla

Question 7

Clilostazol, dipyridamole

Answer 7

Blocks phosphodiesterase and decrease cAMP in plt

Question 8

Thrombolytics (alteplase, streptokinase, reteplase)

Answer 8

Aids in conversion of plasminogen to plasmin — cleaves thrombin and fibrin clots
INC PT/aPTT, no change in platelet count

Question 9

Bleomycin

Answer 9

Induce Free radicals → breaks in DNA of tumor cells

Question 10

Dactinomycin (actinomycin D)

Answer 10

Intercalates on DNA → prevents RNA synthesis

Question 11

Anthracyclins (doxonibicin, daunorubicin)

Answer 11

Generate Free radicals
Breaks DNA → Dec replication
Inhibits topoisomerase 2

Question 12

Thiopurines

Answer 12

Decrease de novo purine synthesis

Question 13

Cladribine

Answer 13

Inhibits ADA → DNA strand breaks

Question 14

Cytarabine

Answer 14

DNA chain termination DNA

inhibits DNA polymerase

Question 15

5-FU and MTX

Answer 15

Dec DTMP → Dec DNA synthesis

Question 16

Hydroxyurea

Answer 16

Inhibits ribonucleotide reductase

Question 17

topoisomerase inhibitor: irinotecan, topotecan

Answer 17

Inhibit topoisomerase 1

Question 18

Topoisomerase inhibitors: etoposide, teniposide

Answer 18

Inhibit topoisomerase 2

Question 19

Tamoxifen

Answer 19

Antagonist → breast binding
agonist - endometrium
blocks binding of estrogen on ER positive cells