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MS 3 > Hema > Flashcards

Hema Flashcards

1
Q

A rapidly progressive neoplasm derived from hematopoietic precursors, or myeloid stem cells that differentiates to monocytes, granulocytes, erythrocytes, and platelets.

Most common type of acute leukemia in adult.

A

Acute Myeloid Leukemia

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2
Q

H

A

H

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3
Q

Uncontrolled proliferation of immatuere cells (lymphoblasts) derived from the lymphoid system.

Most common childhood leukemia

Overall cure rate is more favourable in children than in adults.

A

Acute Lymphoblastic Leukemia

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4
Q

H

A

H

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5
Q

Characterized by the presend of Philadelphia chromosome (Ph1) translocated to chromosome 9; forms bcr-abl gene producing tyrokinase protein.

Arises from the mutation in the myeloid stem cell. Normal myeloid cells is produced but pathologic increse in the production of blast cells.

3 clinical phases: chronic 10%, accelerated 15%, blast crisis >20%

A

Chronic Myeloid Leukemia

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6
Q

H

A

H

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7
Q

H

A

H

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8
Q

Excessive accumulation of mature leukemia cells in the bone marrow and circulation.

Common malignancy in older adults.

A

Chronic Lymphocytic Leukemia

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9
Q

The cancer cells are called Reed-Sternberg cells, an abnormal type of B lymphocytes.

Originates from lymphocytes in the lymphatic system.

A

Hodgkin Lymphoma

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10
Q

What is the infectious agent of these lymphoid malignancies?

Burkitt’s lymphoma
Post-organ transplant lymphoma
Primary CNS diffuse large B cell lymphoma
Hodgkin’s disease
Extranodal NK/T cell lymphoma, nasal type

A

Epstein-Bare virus

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11
Q

What is the infectious agent of these lymphoid malignancies?

Adult T cell leukemia/lymphoma

A

HTLV-I

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12
Q

What is the infectious agent of these lymphoid malignancies?

Diffuse large B cell lymphoma
Burkitt’s lymphoma

A

HIV

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13
Q

What is the infectious agent of these lymphoid malignancies?

Lymphoplasmacytic lymphoma

A

Hep C virus

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14
Q

What is the infectious agent of these lymphoid malignancies?

Gastric MALT lymphoma

A

H. pylori

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15
Q

What is the infectious agent of these lymphoid malignancies?

Primary effusion lymphoma
Multicentic Castleman’s disease

A

Human herpesvirus 8

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16
Q

A malignant proliferation of plasma cells derived from as single clone.

A

Multiple Myeloma

17
Q

Multiple Myeloma

What is/are the clinical finding/s of these underlting causes and pathogentic mechanisms?

Tumor exopansion, production of osteoclast activating factor by tumor cells, osteoblast inhibitory factors

A

Hypercalcemia, osteoporosis, pathologic fractures, lytic bone leions, bone pain

18
Q

Multiple Myeloma

What is/are the clinical finding/s of these underlting causes and pathogentic mechanisms?

Hypercalcemia, light chain deposition, amyloidosis, urate neuropathy, drug toxicity (nonsteroidal antiinflammtory agents, bisphosphonates), contrast dye

A

Renal failure

19
Q

Multiple Myeloma

What is/are the clinical finding/s of these underlting causes and pathogentic mechanisms?

Bone marrow infiltration, production of inhibitory factors, hemolysis, decreased red cell production, decreased erythropoietin levels

A

Easy fatigue/anemia

20
Q

Multiple Myeloma

What is/are the clinical finding/s of these underlting causes and pathogentic mechanisms?

Hypogammaglobulinemia, low CD4 count, decreased neutrophila migration

A

Recurrent infection

21
Q

Multiple Myeloma

What is/are the clinical finding/s of these underlting causes and pathogentic mechanisms?

Hyperviscosity, cryoglobulinemia, amyloid deposits, hypercalcemia, nerve compression, antineuronal antibody, POEMS syndrome, therapy-related toxicity

A

Neurologic symptoms

22
Q

Multiple Myeloma

What is/are the clinical finding/s of these underlting causes and pathogentic mechanisms?

Renal failure, hypercalcemia

A

Nausea and vomiting

23
Q

Multiple Myeloma

What is/are the clinical finding/s of these underlting causes and pathogentic mechanisms?

Interference with clotting factors, antibody to clotting factors, anyloid damage of endothelium, platelet dysfunction, antibody coating of platelet, therapy-related hypercoagulate defects

A

Bleeding/clotting disorder

MS 3 (1 decks)

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