Hema 1 Flashcards

1
Q

Process of cessation/ stopping of bleeding —> clot formation and clot dissolution

A

Hemostasis

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2
Q

Making of blood clot

A

prothrombin

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3
Q

Fibrinolytic substances

A

Anti-thrombic

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4
Q

Bleeding are stopped by

A

Clot formation

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5
Q

Unwanted/ excessive clot formation are prevented by

A

Body’s circulating INHIBITORS

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6
Q

Substance that retards to stops a process or chemical reax

A

Inhibitors

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7
Q

Blood clot that obstructs a blood vessel

A

Thrombus

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8
Q

Mass (clot) of blood or foreign matter carried in the circulation

A

Embolus

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9
Q

Coagulation

A

Clot formation
Process of forming FIBRIN CLOT

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10
Q

FIBRINOLYSIS

A

clot dissolution
Emzymatic breakdown of BLOOD CLOT

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11
Q

ARTERIOsclerosis

A

Abnormal thickening and hardening of walls
Causing loss of elasticity
Impaired blood circulation

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12
Q

ATHEROsclerosis

A

Form of arteriosclerosis in which LIPIDS, CALCIUM, CHOLESTEROL and OTHER SUBSTANCES deposit on the inner walls of arterioles

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13
Q

2 Theories involved in hematopoietic progenitor cells

A
  1. MONOPHYLETIC THEORY
  2. POLYPHYLETIC THEORY
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14
Q

Every cell lineage has its own stem cell

A

POLYPHYLETIC THEORY

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15
Q

All blood cells are derived from a single progenitor cell called PLURIPOTENTIAL HEMATOPOIETIC STEM CELL

Widely accepted theory

A

MONIPHYLETIC THEORY

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16
Q

Normal Hemostasis

A

Primary Hemostasis, Secondary, Fibrinolysis

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17
Q

Cellular Component and Plasma Proteins

A

2 Major Parts of Physiologic Hemostatic System

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18
Q

Cellular Component

A

Platelets
Endothelial Cells
Neutrophils
Monocytes

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19
Q

Plasma Proteins

A

Clot formation — Coagulation
Dissolution of clots — Fibrinolysis
Naturally Occuring Serine Protease Inhibitors — Anti-coagulation

20
Q

Narrowing of the (lumen) diameter of blood vessels

A

Vasoconstriction

21
Q

The goal of Vasoconstriction

A

To decrease blood flow

22
Q

Substance in connective tissue that will activate of platelets, following platelet adhesion, aggregation and secretion

A

Sub-Endothelial Collagen

23
Q

Vasolidation

A

Increases or enlarges the hole in blood vessel

24
Q

Veins carry ____ blood from ___ to ____

A

DEOXYGENATED
Body tissues , Heart

25
Q

It is where blood exchange happens from ____ to veins

A

CAPILLARIES
ARTERIES

26
Q

It carries oxygenated blood from ___ to ___

A

ARTERIES
Heart , the rest of the body

27
Q

Outermost layer of the blood vessel

A

Vascular ADVENTITA

28
Q

Middle layer

A

VASCULAR MEDIA

29
Q

Innermost vascular lining

Plays an important role in hemostasis

A

VASCULAR INTIMA

30
Q

Lines the vascular intima

Involved in clotting process by PRODUCING and STORING clotting component

A

Endothelial Cells or Endothelium

31
Q

Majority is produced by fibroblast

A

Collagen

32
Q

Lies just beneath the endothelial cells

A

Supporting the ECS

33
Q

Internal Elastic Lamina is composed of:

A

Elastin and Collagen

34
Q

Sub Endothelial Connective Tissue

A

Veins (Collagen&Fibroblast) / Artery (Collagen, Fibroblast and Smooth Muscle Cells) — because artery is thicker than veins

35
Q

Sub-endothelial CT thick part of Vascular Intima behind the ___

A

Endothelium Cells

36
Q

Lies beneath the endothelial tissues

A

Connective Tissue Matrix

37
Q

Highly active metabolically

A

Endothelium

38
Q

It regulates the permeability of the inner vessel wall

A

Connective Tissue Matrix

39
Q

Endothelium is involved in clotting process by

A

Producing or storing clotting components

40
Q

Platelet binds to non-platelet surfaces (sub-endothelial collagen)

VWF links platelet to exposed sub-endothelial collagen

A

Platelet Adhesion

41
Q

It promotes platelet adhesion

A

VWF
(Von Willebrand Factor)

42
Q

VWF binds ___ via platelet glycoprotein membrane receptor (GP Ib/ IX / V)

A

Platelet

43
Q

Also known as “Giant Bernie”

A

Bernard-Soulier Syndrome (BSS)

44
Q

There is no GP Ib/IX/V platelet membrane receptor but there is giant platelet and decrease of number of platelets in circulation

A

BSS

45
Q

It is the decrease number of platelets in circulation

A

Macrothrombocytopenia

46
Q

VW Disease

A

The VWF is absent or defective