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Hem Onc > Hem Onc 2 > Flashcards

Hem Onc 2 Flashcards

1
Q

Methotrexate applications

A

Breat cancer
Osteosarcoma
Lymphoma
Choriocarcinoma

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2
Q

Methotrexate side effects

A

Mylosuppression
Muscotis
Renal tox

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3
Q

Pemetrxed applications

A

Lung cancer

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4
Q

Pemetrexed side effects

A

Mylosuppression (bad)
Mucositus
Skin rash

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5
Q

Florouracil applications

A

Brest cancer
Colo rectal
Head and neck

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6
Q

ATRA treats:

A

DIC in acute promylocytic leukemia

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7
Q

Pre B cell disease and locations

A

Marrow

Acute leukoblastic leukemia/ lymphoma

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8
Q

Mature naive B cell disease

A

Cll

Mantle cell lymphoma

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9
Q

Germinal cell B cell diseases

A

Diffuse large B cell lymphoma
Focal lymphoma
Burkits
Hodgkins

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10
Q

Plasma cell disease

A

Multiple myeloma

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11
Q

Memory cell disease

A

Marginal cell lymphoma

Chronic LL

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12
Q

CD34

A

Expressed only on stem cells

Not on mature cells

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13
Q

Brentuximab

A

CD30 target
3rd line lymphoma treatment

Chemo smart bomb

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14
Q

Rituximab

A

Targets CD 20

B cell lymphoma

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15
Q

BCL 2

A

Anti apoptosis gene

mutated with t(14:18)
Mutated in follicular lymphoma

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16
Q

cd 20

A

On the surface of mature B cells

Not on the surface of b stem cells or plasma cells

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17
Q

CD56

A

Multiple myeloma marker

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18
Q

CD 38 and CD 138

A

Abnormal and normal plasma cells

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19
Q

Crab

A

Calcium
Renal
Anemia
Bone

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20
Q

Gemcitabine applications

A

Lung and pancreatic cancer

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21
Q

Bortzomib

A

Antibprotease used to treat multiple myeloma

Side effects are neuropathy- this is decreased with subcutaneous admin

22
Q

Cyclophoride applications

A

Breast, osteosarcoma, lymphoma

23
Q

Cyclophoride side effects

A

Mylisuppresikn
GI
Diahrrea
Cystitis because of accumulation of the chemical in the bladder

24
Q

ERCC1

A

DNA repair enzyme

Increased for cisplatin resistance

25
Q

14q32

A

Most common mutation in multiple myeloma

26
Q

Plerixafor

A

Used to increase stem cells in peripheral blood

CDCR - SDF-1 antagonist

27
Q

Cetuximab

A

Outside EGFR antibody

Lung cancer

28
Q

Panitumumab

A

Outside EGFR antibody

Lung cancer

29
Q

Erlotinib

A

Block internal tyrosine kinase activity of EGFR

30
Q

Gefitinib

A

Blocks internal tyrosine kinase activity

31
Q

Trastuzumab

A

Antibody that blocks outside tyrosine kinase activity of her2

32
Q

Pertuzumab

A

Blocks dimerizarikn of her2

33
Q

Lapatinib

A

Blocks internal tyrosine kinase activity of her2

34
Q

Bevacizumab

A

Blocks extra cellular domain of VEGF

35
Q

Sorafinib

A

Blocks internal tyrosine kinase activity of VEGF

36
Q

Sunitinib

A

Blocks internal tyrosine kinase activity of VEGF

37
Q

Diffuse large B cell lymphoma mutation

A

3q27

BCL-6

38
Q

FL markers

A

Cd10

Bcl2

39
Q

Most common lymphomas

A

Dlbcl most common

Fl 2nd

40
Q

9:22

A

Philadelphia chromosome

41
Q

Imatinib

A

Displaces ATP from Phillinchormoske

42
Q

Burkitts Chromosome mutation

A

8:14

43
Q

Mantle cell lymphoma mutation

A

11:14

44
Q

T cell inhibitory interaction

A

B7-CLTA4

45
Q

Excitatory T cell interaction

A

B7- CD28

46
Q

Most common adult acute leukemia

A

aml

47
Q

Xerostomia

A

Dry mouth

48
Q

Bliomyosin toxicity

A

Pulmonary fibrosis

49
Q

Adriamycin side effect

A

Cardiac toxicity

50
Q

CD43

A

Mantle cell

Hem Onc (2 decks)

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