Hellekant Intro To Endo Flashcards
Hormones from the hypothalamus and pituitary are what type of hormones?
Peptides and proteins
In the ER, what happens to the preprohormone?
The ER chops off the signal sequence, creating an inactive prohormone
What organelle is important is synthesizing steroid hormones?
Smooth ER
What tissues make steroid hormones?
Adrenal glands, gonads, placenta
What hormones are considered amine hormones?
Dopamine, norepinephrine, epinephrine, and thyroid hormones
What is the parent amino acid for catecholamines and thyroid hormones?
Tyrosine
Where are the receptors for protein hormones located?
On target cell membranes
A hormone binding to Gq activates what? What are the downstream effects?
Phospholipase C; generates second messengers IP3 and DAG
What hormones bind Gq receptors?
Vasopressin, TSH, and angiotensin
Binding of a hormone to a Gs receptor results in activation of what?
Adenylyl cyclase
What hormones bind to Gs receptors?
LH, glucagon, Epinephrine, ACTH, PTH
“Lets Get Every Awesome Person Going South”
What hormone binds Gi? What are the downstream effects?
Somatostatin binds Gi, inhibiting adenylyl cyclase
Steroid hormone receptors are part of what receptor family type?
Nuclear receptor superfamily
In order to get a transcriptional response from a steroid hormone receptor binding, what must form?
Hormone:receptor homodimer
What are the ligands for the RXR hormone receptors?
Thyroid hormones, Vit D receptor, fatty acids
