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Bacteria > Helicobacter > Flashcards

Helicobacter Flashcards

1
Q

General characteristics (2)

A

Gram Negative, Spiral shaped

Microaerophilic

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2
Q

Reservoir

A

MAN ONLY

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3
Q

Transmission (2)

A

ORAL-ORAL or FECAL-ORAL

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4
Q

Habitat

A

Gastric mucosa

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5
Q

Clinical Manifestations (3)

A

Where bacteria are numerous, underlying mucosa shows SUPERFICIAL GASTRITIS

Minority of patients develop PEPTIC ULCER

Long standing infection associated with GASTRIC CANCER

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6
Q

Lab Diagnosis

A

Biopsy UREASE test —> AMMONIA production and change in PH

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7
Q

Reccurence?

A

Elimination of infection allows healing WITHOUT RECCURENCE

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8
Q

Peptic Ulceration (4)

A

1- Production of AMMONIA by UREASE causes IONIC CHANGES in MUCUS layer
2- Production of TOXINS as LIPOOLIGOSACCHARIDE that ACTIVATE INFLAMMATORY CELLS
3- Stimulation of an AUTO-IMMUNE response by production of ANTIGENS that CROSS-REACT with ANTRAL GASTRIC ANTIGENS
4- DEGREDATION of MUCUS by PROTEASE

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Bacteria (24 decks)

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