HEART STUFF

Question 1

Clinical uses of 3rd generation BETA blockers

Answer 1

• used for CHF & HTN
• Reduce BP more than regular BBs, but reduce heart rate less than others
• preferred in metabolic syndrome, don’t negatively affect glucose or lipids

Question 2

Carvedilol

Answer 2

mixed a1-B antagonist so prevents reflex vasoconstriction

protects membrane from lipid peroxidation (antioxidant)

prevents LDL oxidation and uptake by the membrane

Question 3

Labetolol

Answer 3

mixed a1-B antagonist (non selective for beta)

IV for hypertensive emergencies like preeclampsia and pheochromocytoma

Question 4

Nebivolol

Answer 4

B1 selective antagonist + NO mediated vasodilation

antioxidant activity