heart & lung transplant Flashcards
diagnosis for heart transplant
- end stage congestive HF
- ischemic cardiomyopathy
- dilated cardiomyopathy
- congenital heart disease for which no therapy will help
- ejection fraction less than 20%
- intractable angina or malignant cardiac arrhythmias for which no therapy will help
- patient requires mechanical circulatory support or dependent on inotropes
- patients have exhausted all other medical options
diagnosis for lung transplant
- alpha 1 antitrypsin deficiency
- bronchiectasis
- cystic fibrosis
- COPD/emphysema
- lymphangioleiomyomatosis
- pulmonary fibrosis
- pulmonary hypertension
- sarcoidosis
listing process for transplant
- deplete all other medical options
- meet requirements for transplant
- patient is entered into national computerized waiting list, which is maintained by UNOS
matching system based on
- blood type
- tissue type
- size of organ
- medical urgency of patient
- time already spent on waiting list
- geographical distance between donor and recipient
UNOS status classifications for heart allocation
look at notes
lung allocation score
- score from 0 to 100 for each transplant candidate age 12 and older
- estimates the severity of each candidates illness and his or her chance of success following a lung transplant using medical info
- lung allocation score determines waitlist order in addition to blood type and distance between candidate and hospital where organ is located
patient selection and limitations
- an active, uncorrectable infection throughout the body
- HIV or AIDS
- active cancer outside the organ
- active alcoholism or substance abuse
- irreversible, severe brain damage
- severe uncorrectable disease of other organs
- inability or refusal to comply with medical direction
- comprehension
- psychological consideration
- age
donor evaluation
- brain death/hemodynamically stable
- blood/antibody type
- size
- drug abuse
- no malignancies (except brain)
- no infections
- medical history
- cause of death
- first person consent
procurement
- requires careful coordination of several surgical teams
- preservation and packing of organs for transplant
order of organ removal
liver = 8-12 hours
kidney = 24-36 hours
heart = 4-6 hours
lung = 4-6 hours
surgical complications
bleeding, blood transfusions, reperfusion injury, rejection, airway complications, fluid imbalance, infection, phrenic nerve injury, reintubation, rehab, tracheostomy, death
long term complication
hypertension, kidney dysfunction or failure, phrenic nerve injury/damage, diabetes, cancer, high cholesterol, osteoporosis, chronic rejection, recurrent infection
early ICU care
- hemodynamic management
- renal function
- pulmonary function
- immunosuppression
- prevention of rejection/infection
- early mobilization
immunosuppressant meds
- calcineurin inhibitors (cyclosporin, tacrolimus)
- corticosteroids (prednisone)
- anti-proliferative agents (azathioprine, mycophelolate mofetil)
cyclosporine (neoral)
- one of the most effective immunosuppressant meds
- inhibits calcineurin
tacrolimus (prograf)
- 10 to 100 times more potent than cyclosporine
- inhibits calcineurin