Heart Failure (Exam IV) Flashcards
What ejection fraction would characterized HFrEF (heart failure with reduced ejection fraction) ?
≤ 40%
What ejection fraction would characterized HFpEF (heart failure with preserved ejection fraction) ?
≥ 50%
Which type of heart failure is characterized by reduced compliance and restricted left ventricular filling?
LV Diastolic Failure
Which type of heart failure is characterized by reduced contractility, LV dilation, pulmonary congestion, and increased ESV and EDV volumes?
LV Systolic Failure
Systolic dysfunction results in _______ ventricular systolic wall motion.
decreased
What are the four common causes of systolic heart failure?
- CAD
- Dilated Cardiomyopathy
- Chronic ↑ Afterload (HTN, AS, etc)
- Chronic Volume overload
What is the hallmark sign of Chronic LV systolic dysfunction?
EF ≤ 40%
What are common causes of Diastolic Heart Failure?
- CAD
- Chronic HTN
- Chronic AS
Is systolic or diastolic heart failure age-dependent?
Diastolic HF
Which class of diastolic HF is characterized by abnormal LV relaxation but normal left atrial pressures?
Class I
Diastolic HF classes II, III, and IV are characterized by what?
- Abnormal relaxation
- ↓ LV compliance
- ↑ LVEDP
What is acute decompensated HF?
Chronic HF that has developed to become Acute
What is de novo acute HF?
Sudden myocardial dysfunction (ex. MI)
Emergency.
Chronic heart failure features venous ________, but the BP is _________.
congestion; normal
Stroke volume is directly related to ________.
LVEDP
What normal physiologic mechanism contributes to the continued deterioration of chronic HF?
SNS activation
Why does the RAA system get activated in chronic heart failure?
RAAS activated due to decreased renal blood flow
Define afterload.
Pressure needed to open the semi-lunar valves.
Will tachycardia increase or decrease CO in a patient with diastolic HF?
Decrease CO
What is the endocrine response of the heart to chronic HF ?
- ↑ ANP secretion from the atria
- ↑ BNP secretion from the ventricles
What are the physiologic effects of the natriuretic peptides?
- Diuresis
- Natriuresis
- Vasodilation
- Anti-inflammatory
- RAAS & SNS inhibition
ANP and BNP secretion inhibit what two things?
- Hypertrophy
- Fibrosis
What type of hypertrophy is noted by 1 on the figure below?
Concentric Hypertrophy
What type of hypertrophy is noted by 2 on the figure below?
Eccentric Hypertrophy
What auscultated sound is indicative of heart failure?
S3 gallop
What are kerley lines on a chest x-ray ?
Linear opacities caused by interstitial pulmonary edema
What lab value is 90% predictive of a HF diagnosis?
BNP > 500 pg/mL
Describe the NYHA heart failure classification scale.
Describe the 2005 ACC/AHA heart failure classification scale.
What is the Intermacs profile system?
What drug classes are preferred for treatment of HFrEF ?
- β-blockers
- ACE-Inhibitors
What drug class is useful for the control of hypertension and HFpEF?
ARBs
Statins are not recommended in HFrEF patients. T/F?
False. Statin are recommended in all HF patients
When is cardiac resynchronization therapy indicated?
- NYHA class III or IV
- LVEF < 35%
- QRS duration of 120-150 ms