Heart drugs Flashcards
competitive inhibitor of HMG-COA reductase
simvastatin
arteriole dilator
open K+ channels
hydrazaline
calcium channel blocker
angina prophylaxis
toxicity:cardiac depression, bradycardia-heart failure
diltiazem
selective B1 blocker
toxicity:asthma and acute heart failure
atemolol
positive ionotropic cardiac drug
side effect:premature depolarization
milrinone
B1 adenoceptor agonist
side effect: arrhythmias
dobutamine
metabolize to nitric acid
nitroglycerin
prolong refractory period in cardiac muscle
amiodarone
Na+ channel blocker
quinidine
ganglionic blocker
mecamylamine
inhibits intestinal sterol absorption, reduces LDL
exetimbe
increases lipolysis in liver and muscles
GI toxicity
fenobrate
aldosterone target, K+ sparing
acts on collecting tube
spironolactone
angiotensin-converting enzyme inhibitor (ACEI)
reduce salt and water
captopril
3 drugs that reduce atherosclerosis
fenobrate-a fibrate
exetimbe-a fibrate
simvastatin-a statin
4 drugs that relieve angina
hydralazine-casodilator
diltiazem-calcium channel blocker
nitroglycerine
atemolol-B1 blocker
7 drugs that reduce hypertension
Hydralazine-arteriole dilator Atemolol-B1 blocker Mecamylamine-ganglionic blocker Dobutamine- B1 agonist Diltiazem-calcium channel blocker Captopril-ACE inhibitor Spironolactone-aldosterone target, K+ Sparing
4 drugs that reduce cardiac arrhythmias
Quinidine-Na+ blocker
Atemolol- B1 blocker
Amiodarone-prolong refractory period in cardiac mus.
Nitroglycerine-metabolize to nitric oxide
5 drugs that treat heart failure
Hydrazaline-arteriole dilator diltiazem-calcium channel blocker dobutamine-b1 agonist milrinone-positive ionotropic cardiac drug captopril-ace inhibitor
Ideal HDL
~60
anything lower is bad
ideal LDL
<100
130-160 borderline high
>189 very high
ideal triglicerides
<120
>200 high
ideal total cholesterol is _____
high total cholesterol is _____
ideal: <200
high: >240
