Health, Distress, and Impairment Test 3 Flashcards
What are the Severity ratings based on # of symptoms?
Mild= 2-3
Moderate= 4 to 5
Severe= 6 or more
What are the 5 General Categories?
- Depressants (alcohol, sedative hypnotic, anxioylic)
- Stimulants (cocaine, amphetamines, caffeine, tabacco)
- Opioids (heroin, opium, oxy)
- Hallucinogens (cannabis)
- Other (inhalants, steroids, ketamine)
Tolerance
reduction in the effect of a drug as a result of repeated use requires greater quantities to achieve the same effect
Withdrawal
negative physical and psychological effects occur when stopping taking or reducing substance amount
What are the Levels of Substance Involvement?
Use, Intoxication, Abuse, Dependence/Addiction
Physiological Dependence
experience tolerance and withdrawal
What are Depressants
behavioral sedation and can induce relaxation
Examples of Depressants?
Alcohol, sedative, hypnotic and anxiolytic drugs
What occurs in the body with an Increase in Tolerance?
Changes in liver enzymes: efficient metabolism
CNS: changes in the number and sensitivity of GABA and glutamate receptors
What is GABA?
neurotransmitter that blocks impulses between nerve cells in the brain.
What is the function of Glutamate receptors?
mediate fast excitatory synaptic transmission in the central nervous system
What are some Withdrawal Symptoms?
Anxiety, depression, agitation, insomnia, weak, muscle tremors, increased pulse/blood pressure
Delirium Tremens
disorientation, confusion, visual hallucinations, memory problems
Pro-typical heavy drinking
young adult male, not married, financially well-off
Comorbidity
When one illness it accomponied by another: mood and anxiety disorders; personality disorders
What are gender differences in Alcohol use?
Men have a variable pattern and women start later in life following a stressful event and they are less likely to binge
What are the Short Term effects of Alcohol?
Biphasic effect: initial stimulant (increased sociability as alcohol levels rise), followed by depressant (negative emotions as alcohol declines)
What are the Short Term Alcohol effects on Neurotransmitters?
GABA: increased; may reduce tension /anxiety
Serotonin: increased; pleasurable effects and cravings
Dopamine: increased; pleasurable effects
Glutamate: inhibited; slurred speech and memory loss
What are the Long Term effects of Alcohol?
Severe malnutrition, B vitamin deficiency (Korsakoff’s liver syndrome), damaged endocrine glands and pancreas, heart failure, hypertension, reduces immune function (cancer)
What happens to the brain when there is a prolonged heavy use of alcohol?
destruction of grey matter near temporal lobes
Where do Stimulants act?
Brain and sympathetic Nervous System
What are examples of stimulants?
cocaine, caffeine, amphetamines
How do stimulants effect us?
Increases alertness and motor activity
What are the effects of Cocaine?
reduces pain and increases dopamine
What are the effects of Amphetamines?
Increases dopamine and norepinephrine
What are the effects of Caffeine?
Activates noradrenaline neurons and seems to affect the local release of dopamine and adenosine
What are examples of Opioids?
morphine, heroin, codeine, oxy, and fentanyl
What is the function of Heroin?
pain relief, induces sleep
What are the effects of Heroin?
euphoria, drowsiness, daydream state, lack of coordination
What is Methadone?
an opioid medication used to treat severe pain and opioid addiction
What is Demerol/pethidine?
an opioid pain-relief medicine
What feeling is immediate after Herion injection?
warm suffusing ecstasy
When can withdrawal symptoms be felt after injecting Heroin?
8 to 20 hours
What Heroin withdrawal symptoms are felt after 8-20 hours?
influenza symptoms, muscle pains, sneezes, sweats
What Heroin withdrawal symptoms are felt after 36 hours?
More severe, uncontrollable muscle twitching, cramps, chills, increased heart rate/blood pressure, vomiting
How long are Heroin withdrawal symptoms felt?
72 hours
What is Fentanyl?
Potent opioid used for treating severe pain
What counteracts effects of opioids?
Naloxone by blocking the effects of opioids
What are the effects of Hallucinogens?
hallucinations, expansions of consciousness, loss of boundaries, sense of detachment, feeling magically in control
What are examples of Hallucinogens?
Mescaline, psilocybin (shrooms) , PCP (angel dust), LSD, cannabis
Are their withdrawal symptoms for Hallucinogens?
No evidence of any
What would more likely cause a bad trip?
Anxiety which then causes a panic attack
How does Cannabis effect individuals?
If used heavy in teenage years it contributes to psychological problems in adulthood
What are the effects of Inhalants?
Feelings of euphoria and psychic numbing, dizziness, slurred speech, effects are similar to alcohol and damages the CNS
What are examples of Inhalants?
glue, correction fluid, spray paint, gasoline, aerosol sprays, nitrous oxide
What may be a stepping stone in alcohol/drug use disorders?
Inhalants
What are Causes of Addiction?
Biological/genetic, Psychological, Social, Cultural influences
What are the effects of Neurobiological influences in Addiction?
Positively reinforcing- work on internal reward centre dopamine and opioid neurons in mid-brain
Negatively reinforcing- alcohol reduces anxiety (GABA system)
What are the effects of Psychological Influences in Addiction?
Positive and negative reinforcement
Opponent process theory (when an emotion is expressed another is suppressed)
Role of expectancy effects
What are Social Influences in Addiction?
Media, family, peers
Parents and the family appear critical (role of siblings)
Self efficacy: combats peer pressure
What are the Biological Treatments of Substance-Related Disorders?
- Agonist Substitution
- Antagonistic Treatment
- Aversive Treatment
What is Agonist Substitution?
Safe drug with a similar chemical composition as the abused drug e.g methadone for heroin addiction and nicotine gum or patch
What is Antagonistic Treatment?
used to block addictive drugs from activating the brain’s receptors e.g Naltrexone