Healing Response in Acute and Chronic Wounds

Question 1

Category 1 healing

Answer 1

Primary intention

Clean surgical incision - resolves in orderly, sequenced manner over course of approx. 2 weeks

Question 2

Category 2 healing

Answer 2

Delayed Primary Intention

Wound edges are not approximated because of concern for pathogens or debris

Question 3

Category 3 healing

Answer 3

Secondary Intention

Question 4

Category 4 healing

Answer 4

relates to partial thickness skin wounds

Question 5

Acute wound healing is broken down into what phases

Answer 5

1. Hemostasis
2. Inflammation
3. Proliferation
4. Remodeling

Question 6

Hemostasis (phase 1):

Answer 6

Clot formation
BVs VC initially
Coagulation of platelets forms a mechanical trap for pathogens - initiating transition to pro-inflammatory environment

Question 7

Inflammation (phase 2):

Answer 7

Rubor (redness), Tumor (swelling), Calor (heat), Dolor (pain)
Recruitment of neutrophils, leukocytes, macrophages and release of growth factors and pro-inflammatory cytokines

Question 8

Proliferation (phase 3):

Answer 8

4 subphases:
Angiogenesis
Fibroplasia (laying down new collagen)
Matrix Deposition
Re-Epithelialization